Interferons and Other Regulatory Cytokines
This text provides a presentation of the state-of-knowledge of interferons (IFNs) providing a synthetic overview of the role and significance of IFNs in health and disease. Treatment is placed in a broad biological context including much up-to-date background information on the different systems (eg oncogenes or T cell function) that are under the influence of IFNs. This approach makes the book accessible to those not directly involved in IFN research. Coverage also includes other cytokines, such as tumor necrosis factor alpha and beta, and the various interleukins.
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From an Antiviral Factor to a Family of Multifunctional Cytokines
The Interferon Gene Family
Induction of IFNa and IFN8 39
14 other sections not shown
2-5A synthetase Acad amino acid antibodies antiproliferative effect antiviral autoimmune BALB/c binding Biol c-myc Cancer cDNA cell lines cell surface cellular characterized chromosome class II antigens clones cultures cytokines cytotoxic cytotoxic T cells Daudi cells differentiation disease down-regulation dsRNA effect of interferon effects of IFNs enhanced fibroblasts function genomic GM-CSF Gresser growth factor Hu IFN-a IFN production IFN treatment IFN-a and IFN-8 IFN-a genes IFN-induced IFN-treated IFN-y immune interferon Immunol induced inhibition interferon interleukin leukocyte levels locus lymphoblastoid lymphocytes lymphokine macrophages Maeyer Maeyer-Guignard mechanism MHC class mice mitogen molecular molecules monocytes mouse mRNA murine Natl natural killer natural killer cells NK cells normal oncogene patients peripheral blood Proc proliferation receptor recombinant region replication resistant response result role sensitivity sequence specific stimulation structure synthesis T-cell tion TNF-a transcription tumor cells tumor necrosis factor viral Virol virus infection viruses vitro vivo