Interferons and Their Applications
Paul E. Came, William A. Carter
Springer-Verlag, 1984 - Interferon - 575 pages
Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though interferon had achieved success against certain cancers and certain viral diseases, the variability in clinical results was seemingly ever present and little evidence emerged to suggest interferons could cure advanced diseases. Why then the resurgence of an optimistic mood? There are almost always many elements which contribute to happiness, and this is certainly true of the broad frontier of interferon and its place in biochemical research and treatment.
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Acad Sci USA amino acid antibody anticellular antigen antitumor antiviral antiviral activity assay Billiau Biochem biologic Cancer Cantell cDNA cell lines cellular chromosome Clercq clinical cloned cytotoxic disease doses double-stranded dsRNA effects of interferon enhanced etal factor feron Gen Virol Georgiades Goeddel Gresser herpes HuIFN HuIFN-y human fibroblast interferon human IFN human IFN-a human interferon human leukocyte interferon IFN-y Immunol induce interferon inhibition inhibitor inter interferon gene interferon inducers interferon preparations interferon production L-cell leukemia lymphoblastoid lymphoblastoid cells lymphocytes lymphokines macrophages Merigan TC mice mitogens molecule monoclonal antibodies mouse interferon mRNA murine Namalwa cells Natl Acad Sci NK cell NK cell activity nucleic acid nucleotide particles patients PICLC poly(I polynucleotides Proc Natl Acad prostaglandin protein synthesis purified response Sendai virus sensitive serum Soc Exp Biol species Stewart Strander studies terferon tion titers treatment tumor cells U/ml vesicular stomatitis virus Vilcek viral Virology viruses vitro vivo