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a-tocopherol absorption and cleavage acetonitrile adipose tissue animal antioxidant apocarotenals beta-carotene Biochem Biol Chem Caco-2 cells cancer canthaxanthin carotene carotenoids cell line chylomicrons cleavage of P-carotene cleavage products Clin Nutr concentrations conversion of P-carotene cytosol demonstrated dietary dioxygenase assay dose of P-carotene effect enterocyte enzymatic ethanol factors Goodman DS hamsters HPLC increase incubation intestinal absorption intestinal cleavage intestinal dioxygenase activity intestinal mucosa isomers IU vitamin lipoproteins liver liver vitamin lutein lycopene lymph cannulation meal measured method mg P-carotene mmol/L P-carotene absorption P-carotene and retinyl P-carotene cleavage activity P-carotene content P-carotene conversion P-carotene intake P-carotene metabolism P-carotene response P-cryptoxanthin plasma plasma P-carotene plasma response protein S-9 provitamin rat intestinal rats fed reported retinal retinal formation retinoic acid retinoids retinol-binding protein retinyl esters retinyl palmitate Russell RM samples serum small intestine splitsingsactiviteit supplementation triglyceride TRL fraction vitamin A content vitamin A storage vitro vivo P-carotene Wang