Intracellular Protein Degradation
Intracellular protein degradation is becoming an area of widely increasing research. It is central to both normal cellular homeostasis and chronic degenerative and viral diseases. Many of the currently incompletely understood human diseases are in fact protein catabolic disorders of some sort. This important book describes the mechanisms of intracellular protein degradation at the molecular and cell biological levels. Topics include the kinetics of protein degradation, lysosomes, cystosolic proteases, the ubiquitin pathway, molecular determinants of protein half-line, and protein degradation in disease. The book will be invaluable to researchers and students in biochemistry, cell biology, and medicine.
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Proteolytic systems in bacteria
Other signals controlling protein degradation
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8-galactosidase abnormal proteins activity amino acids ATP-dependent autophagic autophagolysosome autophagosomes Biochem Biol calpain cellular Chem complex concentration conjugates culture cells cyclin cytoplasm cytosolic decrease degradation of proteins degradation rate degradation signal destabilizing endoplasmic reticulum endosomes enzymes eukaryotes example fusion proteins genes half-life increase in protein insulin intracellular protein degradation label liver long-lived proteins lysine lysosomal lysosomal degradation lysosomal proteolysis lysosomal system macroautophagy mechanisms membrane microinjection mitochondria molecular molecules multicatalytic protease muscle protein N-end rule N-terminal nitrogen balance non-lysosomal organelle pathway peptide PEST regions phytochrome polypeptide pool protease proteasome protein breakdown protein catabolism protein degradation protein synthesis proteolysis proteolytic proteolytic system radiolabelled rapid rapidly degraded rate of degradation rate of protein rate of synthesis reductase regulated regulatory proteins repressor response reutilization ribosomes Section sequence sequestration serum withdrawal short-lived proteins stabilizing starvation subunits synthesis and degradation target protein test protein tissue tracer ubiquitin ubiquitin-mediated proteolysis Varshavsky vesicles yeast