Introduction to Computational Genomics: A Case Studies Approach

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Cambridge University Press, Dec 14, 2006 - Computers
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Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
 

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Contents

Sequence statistics
1
Chapter
5
Gene finding
22
Sequence alignment
38
Chapter 4
61
within and between species
78
Chapter 6
96
Chapter 7
110
Whole
128
Chapter 9
141
Chapter 10
159
Bibliography
173
Copyright

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About the author (2006)

Nello Cristianini is a Professor of Artificial Intelligence, University of Bristol.

Matthew Hahn is an Assistant Professor at the Department of Biology and School of Informatics, Indiana University.

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