Iron Deficiency and Overload: From Basic Biology to Clinical Medicine

Front Cover
Shlomo Yehuda, David I. Mostofsky
Springer Science & Business Media, Mar 10, 2010 - Medical - 376 pages

Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.

 

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Contents

The Cellular Physiology of Iron
3
Regulation of Iron Absorption and Distribution
31
The Role of Hepcidin in Iron Homeostasis
51
Strategies for Iron Acquisition and Usage by Pathogenic Microorganisms
65
Iron as a Drug and DrugDrug Interactions
77
Iron Overload and Deficiency Pathologies
94
Implications for Cognitive Impairment and Neurodegeneration
95
Role of HO1
125
A Potential Biomarker
223
Alzheimers Dementia
241
Inherited Disorders of Brain Iron Homeostasis
251
Public Health Issues
278
A Review of the Epidemiologic Data
279
Global Concept of Iron Deficiency
299
Nutritional Iron Deficiency in Early Childhood
313
Iron and Womens Health
327

Iron Deficiency and Neuropharmacology
141
Peripheral Effects of Iron Deficiency
159
Lessons from Iron Deficiency and Overloading Pathologies
181
The Effects of Brain Iron Deficiency on Cognitive and Behavioral Aspects
195
Stress Immunology and Cytokines
207
Diagnostic and Clinical Aspects in CNS Disorders
222
Reference Ranges for Common Laboratory Assays of Iron Metabolism
351
Nutritional Sources of Iron
355
Subject Index
359
About the Editors
372
About the Series Editor
373
Copyright

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