Issues in Hematology: 2011 Edition

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ScholarlyEditions, Jan 9, 2012 - Medical - 657 pages

Issues in Hematology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hematology.

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Contents

Experimental Hematology
Hematologic Malignancy
Hematology and Oncology
Hematology Research
Kindlins in FERM adhesion
Association of busulfan and cyclophosphamide conditioning with sleep disorders after hematopoietic stem cell transplantation
Idiotypepulsed antigen presenting cells following autologous transplantation for multiple myeloma may be associated with prolonged survival
Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation
Research from SJ Forman and coauthors in the area of acute lymphoblastic leukemia published
Research in the area of angiogenesis reported from N Pirot and colleagues
Research on blood research detailed by ME Lai and coauthors
Research on myeloid leukemia therapy reported by scientists at University of California
Researchers at Tor Vergata University target myeloid leukemia
Endothelial cell ADAMTS13 and VWF production release and VWF string cleavage
Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence
Can decreasing smoking prevalence reduce leukemia mortality?

Recommendations for the evaluation of risk and prophylaxis of tumour lysis syndrome TLS in adults and children with malignant diseases an expert ...
Unrelated Umbilical Cord Blood Transplantation and Immune Reconstitution
17DMAG targets the nuclear factorkappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia clinical implications of HSP90 in...
The impact of prophylactic freshfrozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in childre...
IgA and IgG hypogammaglobulinemia in Waldenstroms macroglobulinemia
In vitro antimyeloma activity of the Aurora kinase inhibitor VE465
LFA1 activity state on dendritic cells regulates contact duration with T cells and promotes Tcell priming
Lessons from a Case of Oromandibular Mucormycosis Treated with Surgery and a Combination of Amphotericin B Lipid Formulation plus Caspofun...
Higher incidence of relapse in patients with acute myelocytic leukemia infused with higher doses of CD34+ cells from leukapheresis products autogra...
Mechanism of human Hb switching a possible role of the kit receptormiR 221222 complex
Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation
The P2X7nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracell...
Longterm response to deferiprone therapy in Asian Indians
Pulmonary marginal zone Bcell lymphoma of MALT typewhat is a prognostic factor and which is the optimal treatment operation or chemotherapy? ...
Nonmyeloablative umbilical cord blood transplantation
CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NKcell reactivity against human acute myeloid leukemia cells
Development and validation of a pediatric severity index for sickle cell patients
Promoter choice and translational repression determine cell typespecific cell surface density of the inhibitory receptor CD85j expressed on different h...
Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs
Detection of fusion genes at the protein level in leukemia patients via the flow cytometric immunobead assay
Chronic lymphocytic leukaemia a disease of activated monoclonal B cells
Findings from AG Serrano et al in hematopoiesis reported
Findings from MA Dawson and coresearchers advance knowledge in myeloproliferative disorders
Findings in angiogenesis reported from INSERM
Preclinical and clinical progress in hemophilia gene therapy
Use of parenteral iron products and serious anaphylactictype reactions
Donor statin treatment protects against severe acute graftversushost disease after related allogeneic hematopoietic cell transplantation
Incidence of myelodysplastic syndromes within a nonprofit healthcare system in western Washington state 20052006
Optimising the conditioning regimen for acute myeloid leukaemia
Shortcomings in the clinical evaluation of new drugs acute myeloid leukemia as paradigm
ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion
Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5qdel clones a single cell study
Deletion of the p110 beta isoform of phosphoinositide 3kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro a...
Combined 677CC1298AC genotypes of methylenetetrahydrofolate reductase MTHFR reduce susceptibility to precursor B lymphoblastic leukemia in...
Mean corpuscular volume predicts prognosis in MDS patients with abnormal karyotypes
High frequency of MEFV gene mutations in patients with myeloid neoplasm
Bridging therapy and oral anticoagulation current and future prospects
Relevance of target cellinduced apoptosis as mechanism of resistance against natural killer cells
AMPK alpha 2 subunit is involved in platelet signaling clot retraction and thrombus stability
An evolutionarily conserved PTENCEBPalphaCTNNA1 axis controls myeloid development and transformation
Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen
Interstitial insertion of RARa gene into PML gene in a patient with acute promyelocytic leukemia APL lacking the classic t1517
Multiple extrathymic precursors contribute to Tcell development with different kinetics
Advances in the understanding of haemoglobin switching
Classification and diagnosis of myeloproliferative neoplasms according to the 2008 World Health Organization criteria
Identification of a myeloid committed progenitor as the cancerinitiating cell in acute promyelocytic leukemia
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
Interaction of retinoic acid and scl controls primitive blood development
Ribosomopathies human disorders of ribosome dysfunction
Role of Kruppellike factors in leukocyte development function and disease
Syndecan1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines
The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model
Multiple myeloma biology of the disease
Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors
Genetic studies in pediatric ITP outlook feasibility and requirements
Neonatal thrombocytopenia and megakaryocytopoiesis
Expression of the cytoplasmic NPM1 mutant NPMc plus causes the expansion of hematopoietic cells in zebrafish
Plateletassociated IgAs and impaired GPVI responses in platelets lacking WIP
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors release profile and pharmacological modulation
TATmediated transduction of NFYa peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells
Bleeding disorders in Lowe syndrome patients evidence for a link between OCRL mutations and primary haemostasis disorders
Complete remission of splenic marginal zone lymphoma after an acute flareup of hepatitis B in a hepatitis B virus carrier
Identification during the followup of timedependent prognostic factors for the competing risks of death and blast phase in primary myelofibrosis a st...
Early intervention during imatinib therapy in patients with newly diagnosed chronicphase chronic myeloid leukemia a study of the Spanish PETHE...
Extensive softtissue involvement by plasmablastic myeloma arising from displaced humeral fractures
Large scale screening for haemoglobin disorders in southern Vietnam implications for avoidance and management
Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia
Cytogenetic features and prognosis analysis in Chinese patients with myelodysplastic syndrome a multicenter study
The growth factor independence1 Gfi1 is overexpressed in chronic myelogenous leukemia
Activated protein C cofactor function of protein S a critical role for Asp95 in the EGF1like domain
Musclederived Gr1dimCD11b+ cells enhance neovascularization in an ischemic hind limb mouse model
Suppression of Bcell lymphomagenesis by the BH3only proteins Bmf and Bad
Th17Treg ratio in human graftversushost disease
The clinical and biological features of a series of immunophenotypic variant of BCLL
Institute of Child Health Department of Molecular Immunology describes research in life sciences
Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation
Proteomic cell surface phenotyping of differentiating acute myeloid leukemia cells
Phosphatidylinositol 3kinased inhibitor CAL101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and ...
How I treat acute myeloid leukemia
Prognostic factors in adult acute lymphoblastic leukaemia
AMPK a2 subunit is involved in platelet signaling clot retraction and thrombus stability
Humaninduced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
The excess burden of stroke in hospitalized adults with sickle cell disease
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors
MCSF elevates cFos and phosphoCEBPalphaS21 via ERK whereas GCSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to m...
Comparison of plasma levels of natural anticoagulants protein C and protein S among Jordanian smokers and nonsmokers
Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation an update
Detection of sputum Aspergillus galactomannan for diagnosis of invasive pulmonary aspergillosis in haematological patients
The expression of LMO2 protein in acute Bcell and myeloid leukemia
Temporal trends in the proportion cured among adults diagnosed with acute myeloid leukaemia in Sweden 19732001 a populationbased study
GVHD prophylaxis using lowdose cyclosporine improves survival in leukaemic recipients of HLAidentical sibling transplants
NK cells expressing inhibitory KIR for nonselfligands remain tolerant in HLAmatched sibling stem cell transplantation
Role of synectin in lymphatic development in zebrafish and frogs
Krox20EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass
Epidemiology of betathalassaemia in Western India mapping the frequencies and mutations in subregions of Maharashtra and Gujarat
Outcome of adults with sickle cell disease admitted to critical care experience of a single institution in the UK
A high risk of lifethreatening infectious complications in mycophenolate mofetil treatment for acute or chronic graftversushost disease
Molecular monitoring of BAALC expression in patients with CD34positive acute leukemia
MS1020 is a novel small molecule that selectively inhibits JAK3 activity
Pattern of bone mineral density in sickle cell disease patients with the highHb F phenotype
Transforming growth factorbetainduced protein TGFBIpbeta igh3 activates platelets and promotes thrombogenesis
AlloHLA reactivity of virusspecific memory T cells is common
Hematopoietic stem and progenitor cells are differentially mobilized depending on the duration of Flt3ligand administration
Singlecell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms mantle cell lymphoma and Burkitts lymphoma
Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
In vitrodifferentiated Tnatural killercell progenitors derived from human CD34+ cells mature in the thymus
Late effects in survivors of childhood acute lymphoblastic leukemia a study from Thai Pediatric Oncology Group
Expression of microRNA451 in normal and thalassemic erythropoiesis
Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against highdose radiation
Cellcycle regulator E2F1 and microRNA223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
Individual myelomaspecific Tcell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma
Age and platelet count are IPSSindependent prognostic factors in young patients with primary myelofibrosis and complement IPSS in predicting ver...
Autoimmune complications in chronic lymphocytic leukaemia CLL
B7H1 PDL1 CD274 suppresses host immunity in Tcell lymphoproliferative disorders
Circulating microvesicles in Bcell chronic lymphocytic leukemia can stimulate marrow stromal cells implications for disease progression
Complementary and alternative medicine use among longterm lymphoma survivors A pilot study
Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia a report from the Eastern Coop...
TEThered to Runx novel binding partners for runx factors
How I treat postthrombotic syndrome
Immunosuppressive treatment in patient with pure red cell aplasia associated with chronic myelomonocytic leukemia harm or benefit?
Neogenin inhibits HJV secretion and regulates BMPinduced hepcidin expression and iron homeostasis
A noncoding antisense RNA in tie1 locus regulates tie1 function in vivo
NFAT pulls the strings during CD4+ T helper cell effector functions
Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids
An in vivo model of doubleunit cord blood transplantation that correlates with clinical engraftment
Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies
Cord blood transplants one two or more units?
KasabachMerritt phenomenon a single centre experience
Adenovirus capsiddisplay of the retrooriented human complement inhibitor DAF reduces Ad vectortriggered immune responses in vitro and in vivo
Fatal Trichosporon fungemia in patients with hematologic malignancies
Modified nonovert DIC diagnostic criteria predict the early phase of overtDIC
Induction therapy in acute myeloid leukemia intensifying and targeting the approach
Chronic sleep deprivation markedly reduces coagulation factor VII expression
How I treat common variable immune deficiency
Myeloid progenitor cells lacking p53 exhibit delayed upregulation of Puma and prolonged survival after cytokine deprivation
The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0
Characterization of chronic idiopathic thrombocytopenic purpura in Japanese children a retrospective multicenter study
Iron metabolism gene expression in human skeletal muscle
Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse
VH434+ hairy cell leukemia a new variant with poor prognosis despite standard therapy
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis
Comprehensive analyses and characterization of haemophagocytic lymphohistiocytosis in Vietnamese children
Advances in the understanding of MYH9 disorders
Epidemiology of betathalassaemia in Western India mapping the frequencies and mutations in subregions of Maharashtra and Gujarat
Allogeneic virusspecific T cells with HLA alloreactivity do not produce GVHD in human subjects
Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria fungi papillomaviruses and myelodysplasia
Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease
Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish
Granulocyte transfusions in severe aplastic anemia an elevenyear experience
Hypomorphic Rag mutations can cause destructive midline granulomatous disease
Leg ulcers in sickle cell disease
The CD8+ memory Tcell state of readiness is actively maintained and reversible
Safe and feasible outpatient treatment following induction and consolidation chemotherapy for patients with acute leukaemia
New acute lymphoblastic leukemia study findings have been reported from A Oriol et al
New chronic lymphocytic leukemia study findings have been reported by researchers at University zu Koln
New findings from M Borge and coauthors describe advances in leukemia
New findings from V Caruso and coauthors describe advances in lymphoma
New hematology study findings have been published by SJY Pang and colleagues
New leukemia study findings recently were reported by G Gianfaldoni and coresearchers
New pharmacokinetics findings from CF Waller and coauthors described
Differences in the prevalence of growth endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa4966 ligand which specifically targets the platelet thrombus
Lowdose radiation augments vasculogenesis signaling through HIF1dependent and independent SDF1 induction
Comprehensive genomic screens identify a role for PLZFRARalpha as a positive regulator of cell proliferation via direct regulation of cMYC
How I treat acute promyelocytic leukemia
Impact of critical care reconfiguration and trackandtrigger outreach team intervention on outcomes of haematology patients requiring intensive care ...
CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NKcell subsets
How I treat hairy cell leukemia
CYT387 a novel JAK2 inhibitor induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms
Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors
What changes in healthrelated quality of life matter to multiple myeloma patients? A prospective study
Molecular basis of hereditary iron homeostasis defects
Evaluation of the genetic basis of phenotypic heterogeneity in north Indian patients with thalassemia major
Natural history of Southeast Asian Ovalocytosis during the first 3 years of life
An upstream insulator regulates DLK1 imprinting in AML
Improvements in factor concentrates
SOCS3 regulates graftversushost disease
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays need for standardization
Advances in understanding the pulmonary infiltration in acute promyelocytic leukaemia
Recent findings from University Hospital highlight research in acute lymphoblastic leukemia therapy
Recent findings in inflammation therapy described by S Danese and colleagues
Reports by J Berger and coresearchers describe recent advances in bone marrow
Reports from A Giambona et al highlight recent research in hemeproteins
Reports outline blood research study findings from London Research Institute
Reports outline gene therapy research from A Annoni and colleagues
Research conducted at K Juelke and coauthors has provided new information about cytokines
Research findings from A Giambona et al update understanding of hematology
Research from JR Berenson and coresearchers in the area of monoclonal gammopathy of undetermined significance described
The risk of spinal haematoma following neuraxial anaesthesia or lumbar puncture in thrombocytopenic individuals
The impact of a regular erythrocytapheresis programme on the acute and chronic complications of sickle cell disease in adults
Sequence of administration and methylation of SOCS3 may govern response to gemtuzumab ozogamicin in combination with conventional chemoth...
Alternative modes of GMCSF receptor activation revealed using activated mutants of the common betasubunit
Gangrenous cheilitis associated with alltrans retinoic acid therapy for acute promyelocytic leukemia
The impact of bleeding history von Willebrand factor and PFA100174 on the diagnosis of type 1 Von Willebrands disease results from the European...
HS1 has a central role in the trafficking and homing of leukemic B cells
Differentiation of type 1 T regulatory cells Tr1 by tolerogenic DC10 requires the IL10dependent ILT4HLAG pathway
In vivo delivery of a microRNAregulated transgene induces antigenspecific regulatory T cells and promotes immunologic tolerance
The therapeutic response and clinical outcome of adults with ALL1MLLAF4 fusion positive acute lymphoblastic leukemia according to the GIMEM...
Acute leukaemias of ambiguous lineage in children characterization prognosis and therapy recommendations
The genetics of normal platelet reactivity
BetaspectrinBari a truncated betachain responsible for dominant hereditary spherocytosis
Predictive value of F18FDG hybrid PETCT for the clinical outcome in patients with nonHodgkins lymphoma prior to and after autologous stem cell t...
Aspects of anticoagulation in children
A case report of acute lymphoblastic leukemia complicated by lactic acidosis
Laboratory monitoring of new anticoagulants
Plasma levels of advanced glycation end products are associated with haemolysisrelated organ complications in sickle cell patients
Inflammation induces lymphangiogenesis through upregulation of VEGFR3 mediated by NFkappaB and Prox1
The endocytic adaptor Numb regulates thymus size by modulating preTCR signaling during asymmetric division
The management of pregnancy in paroxysmal nocturnal haemoglobinuria on long term eculizumab
Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells
Immunologic minimal residual disease detection in acute lymphoblastic leukemia a comparative approach to molecular testing
Late effects and quality of life of childhood cancer survivors part 1 Impact of stem cell transplantation
Late effects and quality of life of childhood cancer survivors Part 2 Impact of radiotherapy
Eosinophilic myeloid disorders new classification and novel therapeutic strategies
Novel mutations in the inhibitory adaptor protein LNK drive JAKSTAT signaling in patients with myeloproliferative neoplasms
Current therapeutic approaches for patients with myelodysplastic syndromes
Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia the Southwest Oncology Group SWOG experience
Increased adhesive properties of platelets in sickle cell disease roles for alphaIIb beta3mediated ligand binding diminished cAMP signalling and incre...
Increased expression of APAF1 in lowrisk myelodysplastic syndrome a possible role in the pathophysiology of myelodysplasia
Studies conducted at University Hospital on quality of life recently published
Studies from I Andolfo and coresearchers in the area of hematology published
Studies from Kings College London yield new data on hematology
Studies from L Pagano and coresearchers in the area of hematology published
Study data from Childrens Hospital Division of HematologyOncology provide new insights into apoptosis
Study data from Cleveland Clinic update knowledge of life sciences
Study results from MT Bertilaccio et al provide new insights into xenotransplantion
Stem and progenitor cells in human umbilical cord blood
Efficacy and Safety of Micafungin as an Empirical Antifungal Agent for Febrile Neutropenic Patients with Hematological Diseases
Predictors of response to immunosuppressive therapy with antithymocyte globulin and cyclosporine and prognostic factors for survival in patients wi...
Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood
Successful treatment of biphasic metaplastic sarcomatoid carcinoma of the breast by evaluation of immunohistochemical markers
Aurora kinases A and B are upregulated by Myc and are essential for maintenance of the malignant state
Effect of general and epidural anesthesia on hemostasis and fibrinolysis in hepatic patients
Role of tyrosine phosphatase SHP1 in the mechanism of endorepellin angiostatic activity
Bag1 directly routes immature BCRABL for proteasomal degradation
Successful engraftment after reducedintensity umbilical cord blood transplantation for myelofibrosis
Human multipotent mesenchymal stromal cells use galectin1 to inhibit immune effector cells
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets
HLAmismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumabbased reducedintensity con...
Managing anticoagulated patients during neuraxial anaesthesia
Increased risk of ALL among premature infants is not explained by increased prevalence of preleukemic cell clones
Generation and phenotypic analysis of protein Sdeficient mice
Treatment of acute promyelocytic leukemia with PETHEMA LPA 99 protocol a Tunisian single center experience
Umbilical cord blood transplantation from unrelated donors in adult patients with chronic myeloid leukaemia
Coexpression of the Tcell receptor constant alpha domain triggers tumor reactivity of singlechain TCRtransduced human T cells
Erythrocytosis associated with a novel missense mutation in the HIF2A gene
Tumor necrosis factoralpha promoter variants and iron phenotypes in 785 hemochromatosis and iron overload screening HEIRS study participants
Spatial gradients of blood vessels and hematopoietic stem and progenitor cells within the marrow cavities of the human skeleton
Cardiac magnetic resonance in transfusion dependent thalassaemia assessment of iron load and relationship to left ventricular ejection fraction
Is MRD eradication a desirable goal in CLL?
The embryonic origins of lymphatic vessels an historical review
ATGinduced expression of FOXP3 in human CD4+ T cells in vitro is associated with Tcell activation and not the induction of FOXP3+ T regulatory ...
Genomewide copy number analysis of Hodgkin ReedSternberg cells identifies recurrent imbalances with correlations to treatment outcome
Orai1 regulates intracellular calcium arrest and shape polarization during neutrophil recruitment in shear flow
Molecular pathways to CML stem cells
Role for ADAP in shear flowinduced platelet mechanotransduction
Signaling circuitry in vascular morphogenesis
AT9283 a potent inhibitor of the Aurora kinases and Jak2 has therapeutic potential in myeloproliferative disorders
Comparison of different criteria for the diagnosis of primary myelofibrosis reveals limited clinical utility for measurement of serum lactate dehydrog...
Synergism between platelet collagen receptors defined using receptorspecific collagenmimetic peptide substrata in flowing blood
Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom General Practice Research Database
The optimal use of steroids in paediatric acute lymphoblastic leukaemia no easy answers
Targeting paediatric acute lymphoblastic leukaemia novel therapies currently in development
gp96 an endoplasmic reticulum master chaperone for integrins and Tolllike receptors selectively regulates early T and B lymphopoiesis
Leukemogenic transformation by HOXA cluster genes
High resolution SNP array genomic profiling of peripheral T cell lymphomas not otherwise specified identifies a subgroup with chromosomal aberrat...
Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells
ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug
Aspergillus PCR testing results from a prospective PCR study within the AmBiLoad trial
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
Oral Xa inhibitors
HTLVI Taxdependent and independent events associated with immortalization of human primary T lymphocytes
Munc134 is a limiting factor in the pathway required for platelet granule release and hemostasis
Association of coagulation factor XIIIA with Golgi proteins within monocytemacrophages implications for subcellular trafficking and secretion
Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function
Akt is activated in chronic lymphocytic leukemia cells and delivers a prosurvival signal the therapeutic potential of Akt inhibition
The biology of hairycell leukaemia
Optimization of isolation and further characterization of umbilical cord bloodderived very small embryonic epiblastlike stem cells VSELs
Nonsensemediated mRNA decay NMD blockage promotes nonsense mRNA stabilization in protein 41R deficient cells carrying the 41R Coimbra vari...
The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis
Novel interactions between UFH and TFPI in children
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells
Allogeneic T regulatory cellmediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance
Epigenetic regulation of the alternatively activated macrophage phenotype
Molecular characterization of inframe and outofframe alternative splicings in coagulation factor XI premRNA
Natural killer cells and tumor control
Haematopoeitic cell transplantation for Fanconi anaemia when and how?
Depletion of endogenous tumorassociated regulatory T cells improves the efficacy of adoptive cytotoxic Tcell immunotherapy in murine acute myel...
Infectious complications of chronic lymphocytic leukaemia pathogenesis spectrum of infection preventive approaches
The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickl...
The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells
A variant allele of Growth Factor Independence 1 GFI1 is associated with acute myeloid leukemia
A population pharmacokinetic model for pegylatedasparaginase in children
Maintenance therapy in acute myeloid leukemia revisited will new agents rekindle an old interest?
Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and singlelineage marrow failure a pilot study and a survey f...
Optimizing management of immune tolerance induction in patients with severe haemophilia A and inhibitors towards evidencebased approaches
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
Glycoprotein Ib alpha inhibitor complex structure reveals a combined steric and allosteric mechanism of von Willebrand factor antagonism
Autophagy contributes to therapyinduced degradation of the PMLRARA oncoprotein
Alternative activation of macrophages by IL4 impairs phagocytosis of pathogens but potentiates microbialinduced signalling and cytokine secretion
microRNA expression in erythropoiesis and erythroid disorders
New mechanism for Notch signaling to endothelium at a distance by Deltalike 4 incorporation into exosomes
Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia an individ...
Molecular aspects of myeloproliferative neoplasms
Highmobility group protein HMGB2 regulates human erythroid differentiation through transactivation of GFI1B transcription
Does cytogenetic evolution have any prognostic relevance in myelodysplastic syndromes? A study on 153 patients from a single institution
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM and integrinmediated signaling in platelets
Treatment options in heparininduced thrombocytopenia
Treatment advances in posttransplant lymphoproliferative disease
Evaluation of thrombocytopenia in the acute coronary syndrome
Hb Baden structural and functional characterization
Plateletderived thrombospondin1 is a critical negative regulator and potential biomarker of angiogenesis
TRAF6 inhibits Th17 differentiation and TGFbetamediated suppression of IL2
Akt1 and Akt2 promote peripheral Bcell maturation and survival
cMyb Menin GATA3 and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development
Adult hematopoietic stem cells require NKAP for maintenance and survival
Differential ability of Tribbles family members to promote degradation of CEBPalpha and induce acute myelogenous leukemia
Platelets regulate lymphatic vascular development through CLEC2SLP76 signaling
Self inhibition of phagocytosis the affinity of marker of self CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels
Toxicities of the thrombopoietic growth factors
Tolllike receptorinduced changes in glycolytic metabolism regulate dendritic cell activation
Multilineage dysplasia has no impact on biologic clinicopathologic and prognostic features of AML with mutated nucleophosmin NPM1
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area
mTOR and GSK3 shape the CD4+ Tcell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS
PGE2 transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5
The role of thromboprophylaxis in cancer patients emerging data
The genetic basis of Von Willebrands disease
Myeloma cellinduced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclastmyeloma hybrid cells
Healthrelated quality of life following haematopoietic cell transplantation patient education evaluation and intervention
Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo
Influenza Apandemic 2009H1N1 in the setting of allogeneic hematopoietic cell transplantation a potentially catastrophic problem in a vulnerable pop...
Evidence for a common genetic aetiology in highrisk families with multiple haematological malignancy subtypes
15Shydroxyeicosatetraenoic acidinduced angiogenesis requires Srcmediated Egr1dependent rapid induction of FGF2 expression
Advances in hemophilia experimental aspects and therapy
Vascular complications after splenectomy for hematologic disorders
ASH 2009 meeting reportTop 10 clinically oriented abstracts in acute leukemia
Homologous recombination as a resistance mechanism to replicationinduced doublestrand breaks caused by the antileukemia agent CNDAC
Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy druginduced apoptosis
Evi1 as a critical regulator of leukemic cells
IgGassociated immune thrombocytopenia in Waldenstrom macroglobulinemia
Frontline treatment of acute promyelocytic leukemia with AIDA induction followed by riskadapted consolidation for adults younger than 61 years re...
Comparison of human cord blood engraftment between immunocompromised mouse strains
Key players for Tcell regeneration
Human Siglec10 can bind to vascular adhesion protein1 and serves as its substrate
Induction of FPN1 transcription by MTF1 reveals a role for ferroportin in transition metal efflux
Netrin4 induces lymphangiogenesis in vivo
ZAP70 expression is associated with increased risk of autoimmune cytopenias in CLL patients
A functional screen for regulatory elements that improve retroviral vector gene expression
Sequential phase II Southwest Oncology Group studies S0112 and S0301 of daunorubicin and cytarabine by continuous infusion without and with ci...
ADFncofilindependent actin turnover determines platelet formation and sizing
The Haematological Malignancy Research Network HMRN a new information strategy for population based epidemiology and health service research
Melphalan 200 mgm2 versus melphalan 100 mgm2 in newly diagnosed myeloma patients a prospective multicenter phase 3 study
A role for factor XIIamediated factor XI activation in thrombus formation in vivo
The BH3only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3KAkt and MEKERK12 pathways
The panHDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
Critical roles for cMyb in lymphoid priming and early Bcell development
Elevated Mcl1 perturbs lymphopoiesis promotes transformation of hematopoietic stemprogenitor cells and enhances drug resistance
Platelet senescence is regulated by an internal timer not damage inflicted by hits
A proteaseresistant PMLRARalpha has increased leukemogenic potential in a murine model of acute promyelocytic leukemia
ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling
Latent herpesvirus infection arms NK cells
The blast phase of chronic myeloid leukaemia
Translation regulation of Runx3
Forceinduced cleavage of single VWFA1A2A3 tridomains by ADAMTS13
Serum response factor is an essential transcription factor in megakaryocytic maturation
Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells
Lymphotoxinalpha contributes to lymphangiogenesis
Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gauchers disease effect on incidence of avascular necrosis
Genetic polymorphisms in the metabolic pathway and nonHodgkin lymphoma survival
Serum HO1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions
Qualitative and quantitative differences in the intensity of Fasmediated intracellular signals determine life and death in T cells
Hemoglobin Research
Laboratory Hematology
Molecular Blood Research
Platelet Research
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