Knowledge Exploration in Life Science Informatics: International Symposium KELSI 2004, Milan, Italy, November 25-26, 2004, Proceedings

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Springer Science & Business Media, Nov 22, 2004 - Computers - 248 pages
This volume of the Springer Lecture Notes in Computer Science series contains the contributions presented at the International Symposium on Knowledge Exploration in Life Science Informatics (KELSI 2004) held in Milan, Italy, 25-26 November 2004. The two main objectives of the symposium were: - To explore the symbiosis between information and knowledge technologies and v- ious life science disciplines, such as biochemistry, biology, neuroscience, medical research, social sciences, and so on. - To investigate the synergy among different life science informatics areas, including cheminformatics, bioinformatics, neuroinformatics, medical informatics, systems - ology, socionics, and others. Modern life sciences investigate phenomena and systems at the level of molecules, cells, tissues, organisms, and populations. Typical areas of interest include natural e- lution, development, disease, behavior, cognition, and consciousness.This quest is g- eratinganoverwhelmingandfast-growingamountofdata, information, andknowledge, re?ecting living systems at different levels of organization. Future progress of the life sciences will depend on effective and ef?cient management, sharing, and exploitation of these resources by computational means.
 

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Contents

A PenandPaper Notation for Teaching Biosciences
1
An Exploration of Some Factors Affecting the Correlation of mRNA and Proteomic Data
9
Improving Rule Induction Precision for Automated Annotation by Balancing Skewed Data Sets
20
A Randomized Algorithm for Distance Matrix Calculations in Multiple Sequence Alignment
33
Extracting Sequential Patterns for Gene Regulatory Expressions Profiles
46
Data Analysis of Microarrays Using SciCraft
58
Functional Data Analysis of the Dynamics of Gene Regulatory Networks
69
Text Mining of Full Text Articles and Creation of a Knowledge Base for Analysis of Microarray Data
84
Teaching Grasping to a Humanoid Hand as a Generalization of Human Grasping Data
139
JavaSpaces An Affordable Technology for the Simple Implementation of Reusable Parallel Evolutionary Algorithms
151
Detecting and Adapting to Concept Drift in Bioinformatics
161
Feature Extraction and Classification of the Auditory Brainstem Response Using Wavelet Analysis
169
Evaluation of Outcome Prediction for a Clinical Diabetes Database
181
Cytochrome P450 Classification of Drugs with Support Vector Machines Implementing the Nearest Point Algorithm
191
MultipleInstance CaseBased Learning for Predictive Toxicology
206
Modelling and Prediction of Toxicity of Environmental Pollutants
221

Through Biomedical Literature Text Mining of Abstracts vs Text Mining of Full Text Articles
96
Investigating Performance Local Search and Homonymy Recognition
109
A Worm with a Bayesian Brain
124
Procedures to Standardize Data and Compare Models
235
Author Index
249
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