Lead Molecules from Natural Products: Discovery and New Trends

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Elsevier, Jul 7, 2006 - Science - 448 pages
Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research.

This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.

The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations.

* Explains the effects of plant extracts on gene expression profiling.

* Details medicinal plant research from around the world

* Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.
 

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Contents

a new concept for accelerating natural drug discovery
1
from macroarrays to microarray technology
21
Effects of medicinal plant extracts on molecular interactions between DNA and transcription factors
35
from biologically active molecules to drugs
45
Herbal extracts and compounds active against herpes simplex virus
65
Pharmacological modulation of cough reflex
87
Phytotherapy of cough
111
The medicinal potential of black seed Nigella sativa and its components
133
the case of Croton cajucara
225
Antihypertensive peptides from natural resources
255
chemistry and pharmacology
273
Inhibition of immunodeficiency type1 virus HIV1 life cycle by medicinal plant extracts and plantderived compounds
299
Anticancer properties of saffron Crocus sativus Linn
313
Lead compounds and drug candidates from some Turkish plants for human health
331
Molecular design of multifunctional antiSalmonella agents based on natural products
353
Plant growth inhibitory activities by secondary metabolites isolated from Latin American flora
373

recent advances and future prospects for cancer treatment
155
Anticancer and medicinal properties of essential oil and extracts of East Mediterranean sage salvia triloba
169
Marine organisms from Brazil as source of potential anticancer agents
181
Anticancer potential of Northeast Brazilian plants
197
Safety and efficacy of phytomedicines
213
Metabolomics systematic studies of the metabolic profiling
411
Contributors
421
Index
425
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