Lentiviruses and Macrophages: Molecular and Cellular Interactions

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Moira Desport
Horizon Scientific Press, 2010 - Science - 345 pages
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Lentiviruses comprise a genus of diverse viruses in the Retroviridae family which are united in their ability to infect and persist in macrophages. Infections are characterized by immune system dysfunctions following sometimes lengthy incubation periods. The viruses in this genus include primate lentiviruses, such as HIV, as well as animal lentiviruses, including equine infectious anemia virus (EIAV). An intriguing feature of lentiviruses is their ability to hijack macrophages so that they are simultaneously involved in the dissemination and control of virus spread throughout the host, leading to disease induction and/or transmission to a new host. Macrophage biology is at an exciting stage with a wealth of new information being generated, as their role is dissected in parasitic, viral, and bacterial infections, as well as in chronic inflammatory and autoimmune disease. Despite the devastating infections that lentiviruses cause, they also have enormous potential as research tools due to their ability to integrate into the host genome and are being exploited for use as delivery vehicles in gene therapy. Understanding the lentiviral-macrophage interaction is vital for developing novel antiviral strategies and will permit their use as research tools to be fully realized. Research in this area has never been more exciting! In this timely book, top lentivirus and macrophage specialists comprehensively review cutting-edge topics in the molecular and cellular biology of the lentivirus-macrophage interaction. Topics include: lentivirus tropism and disease, macrophage biology, macrophage in HIV-1 infection and disease progression, post-entry restrictions to lentiviral replication, HIV-2 tropism and disease, SHIV model of disease, the felid immunodeficiency viruses, EIAV, small ruminant lentiviruses, bovine lentiviruses, coinfections, and superinfections. Essential reading for every lentivirologist and retrovirologist, this is also a recommended text for all virology, immunology, and molecular biology laboratories.

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A Birdseye View of Macrophage Biology
The Macrophage in HIV1 Infection and Disease Progression
Postentry Restrictions to Lentiviral Replication
HIV2 Tropism and Disease
SimianHuman Immunodeficiency Virus Model of Disease
SIV Pathogenic and Nonpathogenic Infections
Viral Cell Tropism and
Equine Infectious Anaemia Virus Pathogenesis and Replication
Small Ruminant Lentiviruses and Crossspecies Transmission
Pathogenesis and Cell Tropism
Lentivirus Coinfections and Superinfections

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