Lipid Mediators and Their Metabolism in the Brain

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Springer Science & Business Media, Aug 12, 2011 - Medical - 327 pages
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Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.
 

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Contents

Metabolism and Roles of Eicosanoids in Brain
1
Recent Development on the Neurochemistry of Docosanoids
49
Metabolism Roles and Involvement of Lysoglycerophospholipids in Neurological Disorders
73
PlateletActivating Factor in Brain Its Metabolism Roles and Involvement in Neurological Disorders
107
Cannabinoids in the Brain Their Metabolism Roles and Involvement in Neurological Disorders
133
Neurochemical Aspects of 4Hydroxynonenal
159
Isoprostanes and Other Nonenzymic Polyunsaturated Fatty AcidDerived Lipid Mediators in the Brain
193
Ceramide and Ceramide 1 Phosphate in the Brain
217
Sphingosine and Sphingosine 1 Phosphate in the Brain
245
Cholesterol and Hydroxycholesterol in the Brain
267
Perspective and Direction for Future Studies on Lipid Mediators
299
Index
315
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About the author (2011)

Dr. Akhlaq A. Farooqui is a leader in the field of signal transduction, brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, and glutamate-induced neurotoxicity. Dr. Farooqui has authored six monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); and Hot Topics in Neural Membrane Lipidology (2009); Beneficial Effects of Fish Oil in Human Brain (2009); and Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases (2010). All monographs are published by Springer, New York. In addition, Dr. Akhlaq A. Farooqui has edited 4 books (Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS (2010) Nova Science Publisher, Hauppauge, N.Y, Molecular Aspects of Neurodegeneration and Neuroprotection, Bentham Science Publishers Ltd (2011); Phytotherapeutics and Human Health: Molecular and pharmacological Aspects, Nova Science Publisher, Hauppauge, N.Y In Press (2011) and Molecular Aspects of Oxidative Stress on Cell Signaling in Vertebrates and Invertebrates, Wiley Blackwell Publishing Company, New York in press, 2011).

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