Lipid Mediators and Their Metabolism in the Brain
Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.
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4-hydroxynonenal activation acyl-CoA acyltransferase adducts agonists Alzheimer’s disease anandamide apoptosis apoptotic cell death arachidonic acid associated astrocytes Bazan Biochem Biol Biophys brain tissue Ca2+ cannabinoid cellular ceramide cerebral Chem cholesterol Collective evidence suggests cPLA2 cyclooxygenase cytokines cytosolic effects eicosanoids endocannabinoid endothelial enzymes EPOX F2-IsoP Farooqui A.A. fatty acids formation function glycerophospholipids hippocampal homeostasis Horrocks human hydrolase hydroxycholesterols increase induces inflammation inflammatory inhibition inhibitors interactions intracellular involved isoforms isoprostanes IsoPs levels lipid mediators lyso-PtdCho lyso-PtdH lysophospholipids macrophages mechanisms metabolism metabolites mice microglia mitochondrial Modulation molecular neural cell neural membrane Neurochem neurodegenerative diseases neuroinflammation neurological disorders neurons neuroprotection Neurosci neurotraumatic NF-kB oxidative stress pathway peroxidation Pharmacol phospholipase A2 phosphorylation PLA2 plasma platelet platelet-activating factor production proinflammatory prostaglandin protein kinase PtdCho receptor regulation release resolvins response role Serhan signal transduction SMase sphingolipid sphingomyelin sphingosine spinal cord stimulation synthase synthesis transcription upregulation