Fiona M. Cunningham
Academic Press, 1994 - Arachidonic acid - 376 pages
This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science.
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Introduction 2 3 4 Metabolic Inactivation of Eicosanoids
Enzymic Conversion of Arachidonic Acid to Prostaglandins Activity
18 other sections not shown
acetylated acetylhydrolase Acta action activating factor acyl-PAF airways analogues anti-inflammatory arachidonic acid aspirin assay asthma binding Biochem Biol biological Biophys biosynthesis blood Camussi Chem Clin clinical compounds cyclooxygenase drugs effects eicosanoids endogenous endoperoxide endothelial cells enzyme eosinophils factor PAF fatty acid formation gastric guinea-pig H]PAF Henson human neutrophils human platelets Hwang Immunol increased indomethacin induced inflammatory inhibition intracellular leukocytes leukotriene B4 lipid lipoxygenase LTB4 LTC4 lung lyso-PAF macrophages mechanism mediators membranes metabolism metabolites Moncada monocytes mucosal Natl Acad neutrophils PAF receptor antagonists PAF synthesis PAF-acether PAF-induced pathway PGD2 PGE2 PGH synthase PGI2 Pharmacol phospholipase A2 Physiol PLA2 plasma platelet platelet aggregation platelet-activating factor potent Proc production prostacyclin prostaglandin E2 prostaglandin endoperoxide prostanoids protein rabbit platelets receptor antagonists release renal response role Samuelsson Smith Snyder specific stimulated studies substrate Thromb thromboxane A2 tissues TXA2 TXB2 Vane vascular vessel wall vitro vivo