Lipoic Acid in Health and Disease

Front Cover
Jürgen Fuchs
CRC Press, Aug 26, 1997 - Science - 504 pages
Reflecting the recent explosion of research into the potent antioxidant properties of lipoate, this up-to-the-minute, single-source reference offers comprehensive presentations on the medical applications of alpha-lipoic acid, emphasizing its potential role in the treatment of diabetes, HIV, atherogenesis, and Parkinson's disease.
 

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Contents

Chemistry Biochemistry and Cell Biology
1
Lipoate Redox Function in Chemical Systems
33
Reaction of Lipoate and Its Derivatives with Reactive Oxygen
47
Overview of the Role of Lipoate in the Enzyme Complexes of
67
AlphaLipoic Acid Stimulates Glucose Transport into Muscle and
87
Lipoic Acid and the Redox Regulation of Apoptosis
99
Lipoate Effects in an AnimalFree Model
131
Pathophysiological Conditions
145
Altered CDeoxyglucose Incorporation in Rat Brain Following
259
Effect of aLipoic Acid on Muscle Glucose Transporters in
269
The
283
aLipoic Acid Treatment of Peripheral Nerve Disease
305
Lipoate Effects on Atherogenesis
321
Medical Applications
337
Implications for the
361
Thioctic Acid Stimulates Muscle ATP Production in Patients with
393

Antioxidant Properties and Effects on Skin
163
Suppression of RadiationInduced Free RadicalMediated Cellular
181
Protection from Myocardial IschemiaReperfusion Injury
193
Neuroprotective Activity of Lipoic and Dihydrolipoic Acid
205
aLipoic Acid and Cataract Risk Reduction
227
Metabolic Alterations in NonInsulinDependent Diabetes Mellitus
243
Treatment with aLipoic Acid in Diabetic Peripheral and Cardiac
407
Lipoate Prevention of Diabetic Microangiopathy
423
Lipoate Prevention of Diabetic Microangiopathy
429
The Effects of Lipoate on Free Radical Production by the
455
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