Liver Growth and Repair

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A. Strain, Anna Mae Diehl
Springer Science & Business Media, Dec 31, 1997 - Medical - 662 pages
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Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
 

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Contents

Nonsurgical nonnecrotizing induction of liver growth
8
Liver regeneration following hepatic injury
28
Alterations in membranemediated events during
34
Epithelial stemlike cells of the rodent liver
50
Transgenic animals as models for hepatocarcinogenesis
100
Gene knockout animal models
143
Biological activity of growth factors in vivo
163
The EGFTGFo family of growth factors and their receptors
185
Part Four Biology of the Extracellular Matrix
403
Regulation of collagen gene expression
430
The extracellular matrix in liver regeneration
451
liver fibrosis
460
Kupffer cells and endothelial cells
482
Hepatic stellate cells
512
Part Five Human Liver Growth and Clinical Applications
539
Human liver growth in fibrosis and cirrhosis
558

Hepatocyte growth factor in liver growth and differentiation
219
The fibroblast growth factor family
240
Cytokines
283
Protooncogenestranscription factors
297
Cyclins and gap junctions in liver growth and repair
311
Intracellular signal transduction in liver regeneration
366
novel applications
577
Hepatic gene therapy
608
Artificial liver support
627
Index
653
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