Liver Regeneration

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Dieter Häussinger
Walter de Gruyter, 2011 - Science - 210 pages
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Understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.

 

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Contents

Process and Prototype
1
2 Oval Cells Bone Marrow and Liver Regeneration
17
3 Inflammation and Liver Regeneration
39
4 Lymphotoxin ? Receptor and Tumor Necrosis Factor Receptor p55 in Liver Regeneration
53
5 The Hepatic Stem Cell Niches
63
6 Stellate Cells in the Regenerating Liver
85
7 Epigenetics during Liver Regeneration
99
8 Hedgehog Signaling and Liver Regeneration
111
9 EGFR CD95 and the Switch between Proliferation and Apoptosis in Hepatic Stellate Cells ...
129
10 Angiogenesis and Liver Regeneration
145
11 A Quantitative Mathematical Modeling Approach to Liver Regeneration
159
12 Animal Models for Studies on Liver Regeneration
175
13 Therapeutic Potential of Bone Marrow Stem Cells in Liver Surgery
191
Index
207
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About the author (2011)

Dieter Häussinger, Heinrich Heine University, Düsseldorf, Germany.

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