Walter de Gruyter, 2011 - Science - 210 pages
Understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.
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Process and Prototype
2 Oval Cells Bone Marrow and Liver Regeneration
3 Inflammation and Liver Regeneration
4 Lymphotoxin ? Receptor and Tumor Necrosis Factor Receptor p55 in Liver Regeneration
5 The Hepatic Stem Cell Niches
6 Stellate Cells in the Regenerating Liver
7 Epigenetics during Liver Regeneration
8 Hedgehog Signaling and Liver Regeneration
9 EGFR CD95 and the Switch between Proliferation and Apoptosis in Hepatic Stellate Cells ...
10 Angiogenesis and Liver Regeneration
11 A Quantitative Mathematical Modeling Approach to Liver Regeneration
12 Animal Models for Studies on Liver Regeneration
13 Therapeutic Potential of Bone Marrow Stem Cells in Liver Surgery