Long-term Tamoxifen Treatment for Breast Cancer

Front Cover
Virgil Craig Jordan
Univ of Wisconsin Press, 1994 - Medical - 289 pages
During the past twenty years tamoxifen has become the most widely prescribed and most successful drug used in the treatment of breast cancer. In this volume, editor V. Craig Jordan provides articles that trace the development, pharmacology, and clinical research surrounding this drug which, by the year 2000, could be used to treat as many as one million women annually.
Drawing from research conducted by specialists in the United States, the United Kingdom, and Italy, the series of articles describes the clinical testing of tamoxifen, highlighting the benefits. Studies show that tamoxifen lowers cholesterol and can potentially protect women against osteoporosis and fatal coronary heart disease. Equally important is a discussion of side effects and possible drug interactions and how these issues relate to patient concerns. An investigation of the development of a new class of drugs for use after tamoxifen fails provides valuable insight into future treatments, as the contributers consider possible resistance to tamoxifen.
This volume provides invaluable information for physicians and surgeons who care for patients with breast cancer and for women interested in exploring this therapeutic dimension.
 

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Contents

The Development of Tamoxifen for Breast Cancer Therapy
3
Clinical Pharmacology and Endocrinology of LongTerm
27
Multisystem Biological and Symptomatic Toxicity
57
Endocrine Therapy for the Premenopausal Woman
83
The Stockholm Adjuvant Tamoxifen Trial
115
Maintenance Tamoxifen after Induction Postoperative
133
Interactions of Tamoxifen with Cytotoxic Chemotherapy
181
TamoxifenResistant Growth
199
A New Approach to Breast Cancer TherapyTotal Estrogen
219
Symptomatic Side Effects of Tamoxifen Therapy
235
The Prevention of Breast Cancer with Tamoxifen
257
Appendix
281
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About the author (1994)

V. Craig Jordan, internationally recognized as an expert on antiestrogens, is professor of cancer pharmacology and director of the Breast Cancer Research Program at Northwestern University. Dr. Jordan has authored numerous articles and edited several books, including the groundbreaking Estrogen/Antiestrogen Action and Breast Cancer Therapy, also published by the University of Wisconsin Press. Dr. Jordan has guided the development of tamoxifen for more than twenty years in an effort to improve breast cancer treatment and women's health.

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