Lung Macrophages in Health and Disease
Bentham Science Publishers, Jan 1, 2009 - Electronic books - 120 pages
This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. the book consists of 8 chapters which provide a full coverage of macrophage function in both healthy and chronically diseased lungs, starting with the regulation of macrophage homoestasis to altered macrophage recognition and clearance of pathogens and apoptotic cells in the lung before moving on to macrophage targeted treatment options for chronic lung diseases. the important problem of oxidative and carbonyl stress in the lung and its impact on macrophage function is discussed. Additional chapters deal with the role of disordered macrophage function in cancer progression and the role of chronic alcohol ingestion of macrophage function. Importantly, the book integrates both respiratory cell biology and clinical medicine. the concept of failed macrophage function with regard to chronic lung disease has recently been the topic of intensive research. Key advances in our knowledge of the cellular and molecular mechanisms involved in defective macrophage function have paved the way for the development of novel diagnostic and therapeutic strategies for diseases such as chronic obstructive pulmonary disease and asthma. for this reason the book can be recommended without reservation to a wide spectrum of readers including students, respiratory cell biologists and respiratory clinicians.
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ABCA3 ABCG1 aeruginosa airway epithelial cells alveolar macrophages anti-inflammatory antigen apoptosis apoptotic cell clearance apoptotic neutrophils asthma azithromycin bacterial binding calreticulin cancer carbonyl Cell Mol Biol Cell Mol Physiol cell surface cellular chronic obstructive pulmonary clearance of apoptotic collectin colony-stimulating factor COPD cystic fibrosis cytokines defect deficient differentiation dysfunction efferocytosis enhanced expression gene GM-CSF Hodge homeostasis human immune response Immunol impaired increased induced infection inflammation inhibition innate immune intracellular kinase ligands lipid Lung Cell Mol macrolides macrophage activation macrophage function macrophage phagocytosis macrophage phenotype mechanisms mediated membrane mice molecules monocytes murine neutrophils obstructive pulmonary disease oxidative stress pathogens pathway Peroxisome proliferator-activated receptor phagocytic phagocytosis phagocytosis of apoptotic phenotype phospholipids Physiol Lung Cell potential PPAR pro-inflammatory production pulmonary alveolar proteinosis recognition regulation Respir Cell Mol Respir Crit respiratory role scavenger receptors signaling SP-A stimulating factor surfactant protein targets therapy tissue type II cells vitro vivo