Lysophospholipid Receptors: Signaling and Biochemistry
The current state of the science supporting new research inlysophospholipids
The study of lysophospholipids exploded with the discovery ofcell surface receptors on both lysophosphatidic acid (LPA) andsphingosine 1-phosphate (S1P). Since then, thousands of originalresearch reports—ranging from fundamental cell signaling tothe physiology and pathophysiology of individual organsystems—have centered on lysophospholipids. This book drawstogether and analyzes the current literature to provide readerswith a state-of-the-science review as well as current techniquesthat support research in all aspects of the field oflysophospholipid signaling.
Lysophospholipid Receptors is divided into threesections:
Within each section, the authors explain the similarities anddifferences between LPA and S1P signaling. Examples are providedthat demonstrate the underlying mechanisms of lysophospholipidsignaling across a broad range of organ systems, such as S1Psignaling in cardiovascular physiology and disease and the neuraleffects of LPA signaling. Extensive references at the end of eachchapter provide a gateway to the literature and facilitate furtherresearch into individual topics.
Each chapter has been authored by one or more leadinginternational authorities in lysophospholipid research. Based on athorough analysis of the current research, the authors set forthwhat is established science and offer their expert opinion andperspective on new and emerging areas of research, setting thestage for further investigations that will solve current problemsin the field.