MOLECULAR AND GENETIC CHARACTERIZATION OF STEROIDOGENIC P450 ENZYMES IN THE MOUSE (STEROID HORMONES, CAMP STIMULATION).

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University of MICHIGAN, 1992 - 93 pages
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any functional consensus CRE's. Treatment of MA-10 cells transiently transfected with the $-$1021 P450$\sb{17\alpha}$-CAT construct with 500 $\mu$M 8-Br-cAMP demonstrated a small increase in CAT expression after 4 h with maximal expression at 12 h. The time necessary for maximal cAMP induction and the absence of consensus CRE's suggests that cAMP stimulation of the mouse P450$\sb{17\alpha}$ gene is not mediated by CRE binding protein(s). The cAMP responsive region was further defined by deletions of the

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Contents

THE STRUCTURAL GENES ENCODING P450scc
21
Results and Discussion
25
References
31

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