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abnormal acid activity alleles Anaesth anesthesia Anesthesiology anesthetics animals B. A. Britt Biochem blood caffeine calcium concentration calcium-induced calcium release cardiac cells chromosome CICR clinical contracture test cytoplasmic dantrolene Denborough diagnosis disease doses drugs effects of halothane Endo erythrocyte fascicles Figure fluorescence gene genetic Gronert halothane halothane-induced increase induced intracellular Kalow Klip laboratory Landrace linkage lymphocytes malignant hyperpyrexia malignant hyperthermia malignant hyperthermia susceptibility markers measured membrane metabolic MH muscle MH reaction MHAUS MHS patients MHS pig MHS swine microelectrode mitochondria muscle biopsy muscle fibers muscle homogenate preparations muscle strips mutation myoplasmic neuroleptic neuroleptic malignant syndrome normal O'Brien Ohnishi plasma Porcine malignant hyperthermia porcine stress syndrome protein release channel Rosenberg ryanodine receptor RYR1 sample sarcoplasmic reticulum sequence skeletal muscle skinned fiber solution stress syndrome succinylcholine susceptible to malignant susceptible to MH temperature tension triggering vitro whole muscle homogenate
Page 314 - Gillard, EF, Otsu, K., Fujii, J., Khanna, VK, de Leon, S., Derdemezi, J., Britt, BA, Duff, CL, Worton, RG, and MacLennan, DH (1991). A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.