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Who gets Malignant Hyperthermia?
Normal muscle structure and function
The mechanism of action of dantrolene sodium
2 other sections not shown
11 patients actin filament action potential anaesthesia Arterial associated blood pressure body temperature caffeine cardiac cardiovascular Central venous cisternae Clinical concentrations confirmed contracture crisis cross bridges Cyclopropane Dantnum Intravenous Dantrium decreasing Denborough described developed diagnosis Diethyl ether disease dose drug Elevated CK Ellis Enflurane fever fibres Figure Gronert et al70 halothane human skeletal muscle hyperkalemia increased inhalation anaesthetics inhalational agent inhibited intracellular calcium intravenous dantrolene sodium malignant hyperpyrexia malignant hyperthermia susceptible malignant hyperthermia syndrome metabolic acidosis Methoxyflurane MH reactions Britt monitoring Muscle abnormalities muscle cell muscle contraction muscle equilibrated muscle relaxants myofibrils Myoglobinuria myosin myosin filaments nitrous oxide normal muscle Number of patients Numberof output oxygen patients 0 20 pigs Platelets potassium power stroke present procainamide procaine produce ratio Relationship between mortality release of calcium respiratory reversed Rigidity sarcomere sarcoplasmic reticulum single agent succinylcholine Survived Britt swine T-tubule tachycardia Tachypnoea treatment of malignant triggering agents troponin twitch