Mammary Tumorigenesis and Malignant Progression: Advances in Cellular and Molecular Biology of Breast Cancer
Robert B. Dickson, Marc E. Lippman
Springer US, Jul 31, 1994 - Medical - 361 pages
The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S.
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Genetic analysis of breast and ovarian cancer in families
The p53 tumorsuppressor gene in human breast cancer
Tumorsuppressor genes in breast cancer progression
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Mammary Tumorigenesis and Malignant Progression: Advances in Cellular and ...
Robert B. Dickson,Marc E. Lippman
No preview available - 2012
Acad Sci USA adhesion allele binding Biochem Biol Chem breast cancer breast cancer cells breast carcinoma breast tumor Cancer Res carcinogenesis carcinoma cells cDNA Cell Biol cell lines cellular chromosome clinical collagen culture detected DFMO differentiation domain ductal E-cadherin effect EGF receptor EGF-like epidermal growth factor epithelial cells estrogen receptor expression fibroblasts fibronectin function gene genetic Ha-ras HMECs hormone human breast cancer human mammary induced inhibition interactions invasive laminin lesions levels ligand Lippman malignant mammary epithelial cells mammary gland mammary tumor MDGF1 membrane metastasis metastatic mice molecular molecule mRNA Natl Acad Sci Natl Cancer Inst oncogene ovarian cancer overexpression p53 mutations patients phenotype phosphorylation plasminogen activator polyamine precursor Proc Natl Acad progesterone prognostic protein regulation role sequence specific steroid stimulation studies synthesis tamoxifen TGF-a TGF-P tissue transcription transforming growth transgenic tumor cells tumor growth tumorigenesis tyrosine kinase variant vitro vivo wild-type