Management of Chemical and Biological Samples for Screening Applications

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Mark Wigglesworth, Terry Wood
John Wiley & Sons, Apr 30, 2012 - Medical - 406 pages
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Filling an obvious gap in the scientific literature, this practice-oriented reference is the fi rst to tie together the working knowledge of large
screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound
acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.
 

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Contents

Introduction to Sample Management
1
Generating a HighQuality Compound Collection
9
Assessing Compound Quality
23
Delivering and Maintaining Quality within Compound
45
Scientific
59
Thinking Lean in Compound Management Laboratories
83
Contents
94
Application ofSupply Management Principles in Sample
107
Applications ofAcoustic Technology
199
Enhancing Biorepository Sample Integrity with Automated Storage
221
Information Technology Systems for Sample Management
243
Key Features ofa Compound Management System
265
What Does an HTS File ofthe Future Look Like?
275
New Enabling Technology
305
The Impact of Future Technologies within Biobanking
351
Outsourcing Sample Management
367

Solid Sample Weighing and Distribution
121
Managing a Global Biological Resource ofCells and Cellular
143
Development ofAutomation in Sample Management
165
Sample Management Yesterday and Tomorrow
381
Index
393
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About the author (2012)

Mark Wigglesworth manages the UK Lead Optimization area of Sample Management Technologies for GlaxoSmith-Kline. Over the past 10 years Mark has managed large and small compound stores, assay ready plate production and compound set provision, as well as interacting with many areas of drug discovery. Additionally, he has led several drug discovery programs and overseen multiple screening platforms providing structure activity relationship data within GlaxoSmithKline's screening organizations.

Now a freelance business consultant, Terry Wood retired in 2011 as the manager of the Liquid Store Centre of Emphasis at Pfizer's world-wide R&D department, based in Sandwich (UK). He has been involved in the high-throughput screening process for the whole of his 25 year career with Pfizer. This has given him a first hand and broad knowledge about the challenges and caveats of assay design, development and
prosecution. His prime responsibility focused on the management of Pfizer's extensive compound file, using a range of automated systems for sample preparation, storage and delivery.

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