Mathematical Modeling in Nutrition and the Health Sciences
Janet A. Novotny, Michael H. Green, Ray C. Boston
Springer Science & Business Media, Oct 31, 2003 - Computers - 420 pages
Overtheyears, research inthelifescienceshasbenefitedgreatlyfromthequantita- tive toolsofmathematics and modeling. Many aspectsofcomplex biological systems can be more deeply understood when mathematical techniques are incorporated into a scientific investigation. Modelingcanbefruitfully applied in many typesofbiological research, from studies on the molecular, cellular, and organ level, to experiments in wholeanimalsandinpopulations. Using the field of nutrition as an example, one can find many cases of recent advances in knowledge and understanding that were facilitated by the application of mathematical modelingtokineticdata. Theavailabilityofbiologicallyimportantstable isotope-labeled compounds, developments in sensitive mass spectrometry and other analytical techniques, and advances in the powerful modeling software applied to data haveeachcontributed toourability tocarryoutevermoresophisticated kinetic studies that are relevant to nutrition and the health sciences at many levels oforganization. Furthermore, weanticipatethatmodeling isonthebrinkofanothermajoradvance: the application of kinetic modeling to clinical practice. With advances in the abilityof modelstoaccesslargedatabases(e. g., apopulationofindividualpatientrecords)andthe developmentofuserinterfaces thatare"friendly"enough tobeused byclinicians who arenotmodelers, wepredictthathealthapplicationsmodeling willbeanimportantnew 51 directionformodelinginthe21 century. This book contains manuscripts that are based on presentations at the seventh conference in a series focused on advancing nutrition and health research by fostering exchange among scientists from such disciplines as nutrition, biology, mathematics, statistics, kinetics, andcomputing. Thethemesofthesixpreviousconferencesincluded general nutritionmodeling(CanoltyandCain, 1985;Hoover-PlowandChandra, 1988), amino acids and carbohydrates (Aburnrad, 1991), minerals (Siva Subramanian and Wastney, 1995), vitamins, proteins, andmodelingtheory(CoburnandTownsend, 1996), and physiological compartmental modeling (Clifford and Muller, 1998). The seventh conference in the series was held at The Pennsylvania State University from July 29 throughAugust1,2000. Themeetingbeganwithaninstructiveandentertainingkeynote address by Professor Britton Chance, Eldridge Reeves Johnson University Professor Emeritus of Biophysics, Physical Chemistry, and Radiologic Physics, University of Pennsylvania. Dr.
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absorption ACSL AKA-Glucose amino acid aminoacyl tRNA analysis animals assumption astrocytes Berman bile biological blood cells body bone brain calcium cancer cell position cholesterol Clin compartment compartmental modeling concentration constant correlation crypts dairy degradation developed Diabetes diet dietary distribution effects energy enzyme equations estimates excretion experimental exponential fatty acids flooding dose function glucose glutamate glutamate metabolism glutamine growth ICP-MS increase initial input insulin sensitivity intake intracellular kinetics labeled lactation liver mammary mass mass spectrometry mathematical modeling measurements milk protein minimal model model prediction native retinoids normal Nutr nutrient Nutrition observed parameters phospholipids plasma pool pyridoxal pyridoxamine pyridoxine radioactivity rats retinol rumen SAAM samples simulation specific radioactivity stable isotope STATA studies subjects substrate synthesis synthetic retinoid tissue tracer tumor turnover uptake values variables vitamin B-6 vivo Wastney weight WinSAAM zinc