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MODELLING AND CELL GROWTH
SOME KINETIC CELL MODELS
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amino acids analysis antigens applied approximation ARA-C assumed assumption behavior Biol biological boundary conditions cancer cancer cells cancer chemotherapy cell cycle cell division cell populations cellular centrioles Chapter chemotherapy chromosomes compartment constant cytoplasm daughter cells defined denoted density function described determined differential equations distribution DNA content DNA histogram DNA synthesis doses drug effect enzymes example experimental exponential growth feedback FLM curve granulocyte granulopoiesis growth rate Hence histogram increase initial conditions input interval kinetics labelled Laplace transform leukemia leukemic cells linear lymphocytes Math mathematical model maturation mean membrane method methotrexate mitosis mitotic molecule myeloblast neutrophil normal cells number of cells obtained optimal control theory output parameters pharmacokinetic phase probability problem proliferating protein ribosomes Rubinow simulation solution solving steady stem cells stochastic synchronized theoretical therapy thymidine tissue total number transfer function tumor tumor cells variable volume yields zero