Mechanisms and Consequences of Proton Transport
Tetsuro Urushidani, John G. Forte, George Sachs
Springer Science & Business Media, Jul 31, 2002 - Medical - 372 pages
This volume represents the proceedings of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Proton Transport" held in Leura, Australia, August 19 -21, 200 I. This conference has been held since 1971 every 3 to 4 years with few exceptions in association with the Congress of the International Union of Physiological Sciences. The first meeting was held in Frankfurt, Germany, at the Max-Planck'Institute. Countries hosting the conference have been Germany (twice), Sweden (twice), India, Canada, USA, Great Britain, and now Australia. Over the past 30 years participants at these Proton Transport Conferences have been principal contributors to the major discoveries in the physiology, biochemistry and pharmacology of gastric acid secretion. These include development of the H2-receptor blockers, defining the signaling pathways for the regulation of acid secretion, identifying the gastric proton pump, discovery and development of proton pump inhibitory drugs, and elucidating the physiology and biochemistry of Helicobacter pylori.
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actin amino acid antibody apical membrane ATPase ATPase activity autoimmune gastritis basolateral binding Biol Chem canalicular capsaicin carbachol cation CD/DMSO channel clathrin concentrations cytoplasmic distal colon domain duodenal effect enzyme epithelial cells expression ezrin F-actin Figure fluorescence forskolin Forte function gastric acid gastric acid secretion gastric glands gastric H,K-ATPase gastric mucosa gastric parietal cells gastritis Gastroenterology gene H.pylori H/K ATPase HCO3 Helicobacter pylori histamine HKca human increase induced infection inhibited inhibitor interaction intestinal intracellular isoforms isolated KCNQ1 kinase luminal mechanism melatonin mg/kg mice microvilli molecular mutants myosin Vb Na,K-ATPase nebulin nongastric ouabain ouabain-sensitive P-subunit parchorin parietal cells permeability PGE2 phosphorylation Physiol protein pylori rabbit gastric rabbit parietal cells Rabl receptor recombinant recycling regulation residues role Sachs secretory signal staining stimulated stomach structure studies subunit tissues transmembrane transport tubules tubulovesicles vesicles