Medaka: A Model for Organogenesis, Human Disease, and Evolution

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Kiyoshi Naruse, Minoru Tanaka, Hiroyuki Takeda
Springer Science & Business Media, May 30, 2011 - Science - 387 pages

Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

 

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Contents

A Glance at the Past of Medaka Fish Biology
1
Genetics Genomics and BiologicalResources in the Medaka Oryzias latipes
18
ChromatinAssociated Periodicity in Genetic Variation Downstream of Transcriptional Start Sites
39
Transposable Elements Tol1 and Tol2
49
A Systematic Screen for Mutations Affecting Organogenesis in Medaka
59
Medaka Bone Development
81
Anatomical Atlas of Blood VascularSystem of Medaka
95
Kidney Development Regeneration and Polycystic Kidney Disease in Medaka
111
Interaction of Germ Cells and Gonadal Somatic Cells During Gonadal Formation
219
Frequent Turnover of Sex Chromosomes in the Medaka Fishes
229
Function of the Medaka Male SexDetermining Gene
241
The SexDetermining Gene in Medaka
255
Endocrine Regulation of Oogenesis in the Medaka Oryzias latipes
269
Interspecific Medaka Hybrids as Experimental Models for Investigating Cell Division and Germ Cell Development
287
Reconstruction of the Vertebrate Ancestral Genome Reveals Dynamic Genome Reorganization in Early Vertebrates
307
Genome Duplication and Subfunction Partitioning Sox9 in Medaka and Other Vertebrates
323

Primary Ciliary Dyskinesia in FishThe Analysis of a Novel MedakaMutant Kintoun
131
p53Deficient Medaka Created by TILLING
157
Medaka Spontaneous Mutants for Body Coloration
173
Craniofacial Traits
185
Double Anal Fin Da A Medaka Mutant Exhibiting a MirrorImage Pattern Duplication of the DorsalVentral Axis
201
Human Population Genetics Meets Medaka
339
Evolution of the Major Histocompatibility Complex A Lesson from the Oryzias Species
351
Molecular Evolution of Teleostean Hatching Enzymes and Their Egg Envelope Digestion Mechanism An Aspect of CoEvol
365
Index
379
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