Medicinal Chemistry: An Introduction

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John Wiley & Sons, Sep 20, 2011 - Science - 646 pages
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Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field.

Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth.

From the reviews of the First Edition:

"It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION

"Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS

 

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Contents

Preface to the First Edition
An introduction to drugs their action and discovery
Drug structure and solubility
Structureactivity and quantitative structure relationships
Computeraided drug design
Combinatorial chemistry
Drugs from natural sources
Biological membranes
Enzymes
Nucleic acids
Pharmacokinetics
Drug metabolism
Complexes and chelatingagents
Nitric oxide
An introduction to drug and analogue synthesis
Drug development and production

Receptors and messengers

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About the author (2011)

Dr Gareth Thomas. The University of Portsmouth, UK

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