Medicinal chemistry: a biochemical approach
Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.
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Physicochemical Principles of Drug Action
Surface activity and drug effects
Stereochemical aspects of drug action
26 other sections not shown
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acetylcholine adenyl cyclase adrenergic affinity agonist alkaloids amino acids analgesic analogues anesthetics Annu antagonist antibiotics antidepressant atom average dose pharmacological bacteria barbiturates benzodiazepine binding sites biochemical biochemistry biological catecholamine cell Chap Chem Chemical cholinergic complex compounds concentration conformation COOH correlations covalent decrease derivatives dopamine dose pharmacological activity drug action drug design drug-receptor effect electron enzyme estrogen function GABA glucocorticoid histamine hormone hydrogen bonds hydrophobic hydroxyl hypotensive increase inhibition inhibitors insulin interaction ionophore label ligand lipid mechanism Medicinal Chemistry membrane metabolism methods methyl mg daily mode of action molecular molecule morphine muscarinic neurons neurotransmitter nicotinic opiate peptide physicochemical presynaptic prostaglandins protein protons reactions receptor regulation release Reproduced by permission result ring Selected Readings serotonin shown in Fig side-chain specific steroid structure structure-activity substituents substrate subunit synaptic synthesis tissue toxic Trends Pharmacol vitamin York