Medicinal chemistry, Volume 2

Front Cover
Alfred Burger
Wiley-Interscience, Dec 2, 1970 - Medical - 1712 pages

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Contents

Poliak I Introduction
798
Riboflavin
800
Niacin Nicotinic Acid
803
Vitamin C Ascorbic Acid
806
Pantothenic Acid
808
Vitamin E Tocopherols
809
Biotin
811
Folic Acid
813
Amines on the Central Nervous System
1281
5Hydroxytryptamine
1282
Cholinergics and Anticholinesterases By James E Gearien I Introduction
1296
Acetylcholine and Analogs
1297
Cholinergics Not Directly Analogous to Acetylcholine
1300
The Receptor Site and Structure Activity Relationships for Cholinergic Drugs
1301
Anticholinesterases
1307
General Anesthetics By A R Paiel I Introduction
1314

Vitamin A
814
Vitamin D
820
Lipoic Acid
822
Pyridoxine Vitamin B
823
Vitamin B 826
826
Vitamin K and Some Dietary Factors
828
Thtroid Hormones and Antithyroid Drugs By Eugene C Jorgensen 1 Introduction
838
Characterization and Synthesis of the Thyroid Hormones Related Iodothyronines and Analogs
843
Structural Requirements for Thyroid Hormonal Activity
845
Theories of Mechanisms of Thyroid Hormonal Activity
850
Antithyroid Drugs
852
Poi peptide and Protein Hormones By G W Anderson
857
Introduction
859
Pancreatic Hormones
860
Neurohypophysial Releasing Factors
863
Kinins
864
Peptide Drugs
865
Oxytocics By 5 N Sawhney I Introduction
868
HI Synthetic Compounds
872
Steroids I The Adrenal Cortex Hormones By Oscar R Rodig 1 Introduction
878
Isolation and Structure
880
Production Site and Occurrence
881
Functions and Bioassays
888
Diseases and Pathological Condi tions Arising from Adrenal Function and Malfunction
889
Approaches to Synthetic Cortisone
890
StructureActivity Relationships
891
Sites and Modes of Action
893
Steroids II Estrogens and Progestational and Contraceptive Agents By R Deghenghi and A J Manson I Introduction
900
Progestational Agents
911
Steroid Oral Contraceptives
915
By R E Counsel and P D Klimstra I Introduction
923
Methods of Bioassay
925
Clinical Evaluation Application and Side Effects
926
Molecular Modifications
928
Absorption Distribution and Metabolic Fate
935
Hypotheses Concerning Structure and Activity
939
Current Research and Future Potential
942
Nonsteroidal Antiinflammatory Agents and Antipyretics By William E Coyne I Introduction
953
Biochemical Properties
954
Pharmacological Testing Methods
956
Antiinflammatory Drugs
958
Current Trends
968
Diuretics By John G Topliss I Physiological Pharmacological and Clinical Considerations
976
Organomercurials
979
Xanthines
982
Thiazines
983
Carbonic Anhydrase Inhibitors
984
Aromatic Sulfonamides
987
Thiazides and Hydrothiazides
998
Aldosterone Antagonists and Inhibitors
1001
Pteridines
1004
Acylphenoxyacetic Acids
1007
Pyrazines
1009
Miscellaneous
1011
Conclusion
1012
Antihypertensive Agents By William T Comer and Allen W Gomoll I Introduction
1019
Sites of Action
1021
Techniques for Evaluation of Antihypertensive Activity
1024
Agents Acting on Central or Reflex Mechanisms
1026
Ganglionic Blocking Agents
1031
Reserpine and Indole Derivatives
1033
Postganglionic Sympathetic
1035
Blocking Agents
1039
Adrenergic ReceptorBlocking
1043
Agents
1048
Agents Acting Directly on Vascular Smooth Muscle
1056
Cardiac Drugs By Charles S Davis and Robert P Halliday I The Cardiac Glycosides
1065
Antianginal Drugs
1078
Coagulants and Anticoagulants By Stephen Divald and Madeleine M Joullie I Mechanism of Blood Clotting
1092
Coagulants
1093
Anticoagulants
1101
Antilipemic Agents By F L Bach I Introduction
1123
Serum Lipids and Lipoproteins
1124
Classification of Hyperlipemic Conditions
1126
Metabolism of Cholesterol
1128
V Drug Regulation of Lipid and Lipoprotein Metabolism
1134
Steroidal Antilipemic Agents
1136
Nonsteroidal Antilipemic Agents
1145
Bile Acid Binding Substances
1164
Hypoglycemic Agents By Frederick A Grunwald I Introduction
1172
Sulfonylureas
1175
Biguanides
1178
Miscellaneous Hypoglycemic Agents
1179
Future Trends in Research on Diabetes and Hypoglycemic Agents
1181
Plasma Expanders By Sharon S Hillery 1 Introduction
1185
Polysaccharides
1186
Polyvinylpyrrolidone
1188
Neuropharmacology By Eugene D Brand and Thomas C Westfall I Introduction
1190
System
1200
Chemical Mechanism and Drug Action
1202
CONTENTS
1209
Chemical Mechanisms and Drug Action
1222
Chemical Mechanisms and Drug Action
1228
Adrenergic Hormones and Drugs By D J Triggle I The Discovery Localization and Distribution of the Adrenergic Transmitter
1235
Sympathomimetic Amines
1238
StructureActivity Relationships
1242
Sympathomimetic Amines
1244
Effects of Sympathomimetic
1263
The Metabolic Actions of Catecholamines
1269
The Structure and Function of Adrenergic Receptors
1273
Electronarcosis
1315
Medicinal Aspects of General Anesthetics
1318
Metabolism of Volatile Anesthetics
1323
Adjuncts to General Anesthesia
1324
W Analgetics By Arthur E Jacobson Eterette L May and Lewis J Sargent I Introduction
1327
Morphine and Congeners
1330
Totally Synthetic Analgetics
1336
Narcotic Antagonists as Analgetics
1344
Considerations
1345
Metabolism and Mode of Action
1346
Antitussives By Paul W Collins I Introduction A
1351
Centrally Acting Antitussives
1352
Peripherally Acting Antitussives
1359
Demulcents
1360
Mucolytic Agents
1361
Hypnotics and Sedatives By Henry G Mautner and Harry C Clemson I Introduction
1365
Early Hypnotics
1366
Barbiturates and Related Compounds
1367
Nonbarbiturate Hypnotics and Sedatives
1374
Muscle Relaxants
1380
Conclusion
1382
Anticonvulsants By Jaime N Delgado and Eugene I Isaacson 1 Epilepsy
1386
The Etiology of Epilepsy
1387
The Pharmacological Evaluation of Anticonvulsants
1389
Absorption and Metabolism
1390
Summary
1398
Analeptics By Leonard M Rice and Edward C Dobbs I Introduction
1402
Xanthines
1403
Picrotoxin
1404
Lobeline
1405
Nikethamide and Ethamivan
1406
Amiphenazole
1407
Antipsychotic Agents By Charles L Zirkle and Carl Kaiser I Introduction
1410
Classes of Antipsychotic Agents
1412
Clinical Aspects
1414
Biological Actions
1418
Effect of Chemical Structure on Antipsychotic Activity
1426
Structure Physical Properties and Neuroleptic Activity
1461
Antidepressant Drugs By Carl Kaiser and Charles L Zirkle I Introduction
1470
Clinical Aspects
1471
Biological Actions
1473
Effect of Chemical Structure on Antidepressant Activity
1475
Antianxiety Agents By Scott J Childress I Introduction
1498
Meprobamate and Analogs
1500
Benzodiazepines
1503
Hallucinogenic Agents By Alfred Burger I Introduction
1511
ill History of Psychedelic Drugs
1512
Clinical Uses
1515
By Edward L Engelhardt and Clement A Stone I Introduction
1528
StructureActivity Relationships in the Polysynaptic Depressants
1529
Muscle Relaxants Other than Polysynaptic Depressants
1535
Antiparkinsonism Drugs By Edward L Engelhardt and Clement A Stone I Introduction
1538
Antiparkinsonism Drugs in Clinical Use
1539
Biochemical Approaches to Parkinsonism
1540
Antispasmodic and Antiulcer Drugs By B V Rama Sastry I Introduction
1544
Biocomparati ve Assay of Anticholinergics
1547
Solanaceous Alkaloids
1548
Synthetic Anticholinergics
1553
StructureActivity Relationships
1561
Interaction of Anticholinergics at the Muscarinic Receptors
1571
Therapeutic Uses of Anticholinergic Agents
1572
Molecular Basis for the Side Effects of Anticholinergics
1573
Profile of Anticholinergic Activities of Various Agents
1574
Curare and Curareform Drugs By Oliver Carrier Jr I Introduction
1581
Curare and Curare Alkaloids
1583
Curareform Alkaloids and Derivatives
1584
Other Curareform Drugs
1588
Conclusion
1594
Ganglionic Stimulants and Blocking Agents By Leonard M Rice and Edward C Dobbs 1 Introduction
1600
Quaternary Ammonium Salts
1601
Tertiary and Secondary Amines
1604
Local Anesthetics By Bertil H Takman and George Camougis I Introduction
1607
Test Methods
1618
Mode of Action
1619
Relationship between Chemical Structure and Biological Activity
1621
General Pharmacology and Toxicology
1623
Metabolism and Distribution
1624
Currently used compounds
1625
Future Developments
1626
Histamine By Jack Peter Green I Chemistry
1633
Formation of Histamine
1634
Catabolism of Histamine
1635
Pharmacological Effects of Histamine
1637
Disease
1638
Drugs and Histamine
1639
Activity of Histamine Analogs
1640
Antiallergenic Agents By Donald T Witiak I Introduction
1643
History of Antihistaminics
1655
Mode of Action of Antihistaminics
1656
Clinical Applications of Antihistaminics
1658
Structure Activity Relationships of Antihistaminics
1659
Histidine Decarboxylase and Inhibitors
1661
Radioprotective Drugs By William O Foye I Introduction
1669
Protective Compounds
1670
Radiosensitizing Agents
1678
Suggested Mechanisms of Protective Action
1679
t Diagnostic Agents By James H Ackerman
1686
Author Index
1
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