Medicinal Chemistry: Principles and Practice
Frank D. King, Royal Society of Chemistry (Great Britain)
Royal Society of Chemistry, Jan 1, 2002 - Medical - 448 pages
This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.
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5-HT2C receptor agonist amino acids analogues analysis animal antagonist application approach assays assessment automated binding bioavailability bioisosteric biological activity blood building blocks candidate cell Chem chemical chemistry clinical combinatorial combinatorial chemistry complex computational concentration conformational cytochrome P450 database descriptors disease dose drug discovery effect enzyme equation example Figure function G-protein G-protein coupled receptors gene genetic genome GlaxoSmithKline high throughput histamine human hydrogen bond identified important increase indolines inhibition inhibitor interactions inverse agonist ion channels kinase large number lead optimisation ligand lipophilicity mechanism medicinal chemist membrane metabolising metabolism methods molecular molecules nuclear receptors parameters patent peptide pharmaceutical pharmacokinetic pharmacophore phase physicochemical plasma potency potential predict protease protein QSAR reaction reagents resin screening selectivity sequence solubility solution-phase specific structure studies substituent substrate synthesis synthetic Table target techniques template tissue toxicity toxicology validation values vitro vivo