Melanins and Melanogenesis

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Academic Press, Dec 2, 2012 - Science - 290 pages
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This volume covers all aspects of melanin pigmentation, providing a concise, comprehensive picture of new knowledge gained at the frontiers of research. It draws heavily on the author's 30-year activity in the field and his continuing work with specialists of widely diverse disciplines. The core of the volume deals with the structure, physicochemical properties, and biosynthesis of the major classes of melanin pigments, including neuromelanins. Further discussions include the biology of the various types of pigment-producing cells, the structure and mode of action of tyrosinase, and the chemistry of urinary melanogens and their biomedical applications as metabolic markers of melanocyte activity, especially for the follow-up of malignant melanoma. Finally, the volume considers progress in the photobiology and photochemistry of melanins, with special emphasis on the controversial role of these pigments in skin photoprotection. Melanins and Melanogenesis is ideally suited as a basic guide for newcomers, and a handy source of specific information for practitioners in academic, medical, and industrial settings.
 

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Contents

CHAPTER 1 An Introduction to Melanin Research
1
CHAPTER 2 MelaninProducing Cells
14
CHAPTER 3 Tyrosinase
34
CHAPTER 4 Natural and Synthetic Melanins
63
CHAPTER 5 Eumelanins
88
CHAPTER 6 Neuromelanin
119
CHAPTER 7 Pheomelanins and Trichochromes
134
Enzymatic and Chemical Control
153
CHAPTER 9 Genetic and Hormonal Regulation of Melanogenesis
185
CHAPTER 10 Photobiology and Photochemistry of Melanogenesis
208
References
225
Index
279
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