Metabolism of Drugs and Other Xenobiotics

Front Cover
Pavel Anzenbacher, Ulrich M. Zanger
John Wiley & Sons, Feb 23, 2012 - Medical - 753 pages
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides
systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews
the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three
main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from
five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse

including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular
toxicology.
Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
 

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Contents

DrugMetabolizing EnzymesAn Overview
3
Cytochromes P450
27
UDPGlucuronosyltransferases
67
Sulfotransferases
117
Glutathione STransferases
147
Hydrolytic Enzymes
165
Transporting Systems
199
Transcriptional Regulation of Human DrugMetabolizing Cytochrome
223
16
415
Tramadol
421
Drugs ofAbuse Including Designer Drugs
429
Nicotine Metabolism and its Implications
465
Metabolism of Alcohol and its Consequences
493
Introduction and Overview
519
Flavonoids
543
St Johns Wort Hypericum perforatum L
583

Importance of Pharmacogenomics
259
Introduction to Drug Metabolism
287
Central Nervous System Drugs
301
Cardiovascular Drugs
331
Anticancer Drugs
365
Antimicrobial Agents
379
Drugs against Acute and Chronic Pain
403
Food Components and Supplements
611
Environmental Pollutants
639
Environmental Estrogens
671
Biotransformation of Insecticides
685
5
695
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About the author (2012)

Pavel Anzenbacher heads the Department of Pharmacology at Palacky University, Olomouc (Czech Republic) and is vicepresident of the Czech Society of Clinical and Experimental Pharmacology and Toxicology. Having obtained his academic degrees from Charles University, Prague and from the Academy of Sciences of the Czech Republic he joined the Faculty of Medicine at Palacky University. His scientific contacts and stays have included e.g. the Princeton University, Vanderbilt University, Nashville, University of Connecticut, INSERM Montpellier, University of Lubeck, Technical University Berlin and Jagellonian University Cracow. Professor Anzenbacher has authored over 150 original scientific publications and has, among other honours, received the Fogarty Award of the USPHS.

Ulrich M. Zanger is deputy head of the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Germany). A chemist by training, he began to work on drug metabolism at the Biocenter of the University of Basel, Switzerland, where he obtained a PhD
degree in biochemistry. He undertook postdoctoral studies at the Southwestern Medical Center at Dallas, Texas, before returning to Basel and later moving to Stuttgart. His major research interests are in human drug metabolizing cytochromes P450 and in basic and clinical aspects
of pharmacogenetics/genomics. Professor Zanger has authored more than 130 scientific articles and is lecturing in pharmacology and toxicology at the University of Tubingen.

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