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Molecular and Somatic Cell Genetics Analysis of Metal Metabolism in Cultured Cells
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abnormal absorption accumulation acid acrodermatitis enteropathica allele amine oxidases animals associated autosomal binding biochemical Biochemistry Biol Bourel cadmium Cd2+ cell lines cellular ceruloplasmin chromium chromosome cirrhosis Clin clinical concentration copper content copper metabolism cultured cells cystic fibrosis Cytochrome Cytochrome c oxidase decreased defect diabetes mellitus disease patients disorder dose effects enzyme ferritin fibroblasts function genetic glucose glucose tolerance hemochromatosis hemochromatosis allele hepatic human hybrids idiopathic idiopathic hemochromatosis induced insulin intestinal intracellular iron overload kidney kinky hair disease liver lysyl oxidase manganese Menkes metal ions metal metabolism metallothionein methylation molecules MT genes MT synthesis mutant non-MT normal observed oral oxidase activity parenteral patients with Wilson's Pediatr phenotypic plasma protein rats Rennert reported resistance response role serum structural gene studies symptoms syndrome therapy tissues toxic Trace Element trace metal treatment variants Wilson's disease X chromosome X-linked zinc deficiency zinc excretion zinc levels Zn2+