Metastasis of Prostate Cancer

Front Cover
Richard J. Ablin, Malcolm D. Mason
Springer Science & Business Media, Jul 18, 2007 - Medical - 407 pages
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.
 

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Contents

Introduction Metastasis as a Therapeutic Target
2
The Natural History of Prostate Cancer
5
The Search for Genes Which Influence Prostate Cancer Metastasis A Moving Target
21
Polyunsaturated Fatty Acids and Prostate Cancer Metastasis
62
Role of Prostaglandin Synthesis and Cyclooxygenase2 in Prostate Cancer and Metastasis
87
Cell Cycle Regulation
110
EpithelialMesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity
127
Orthotopic Metastatic Mouse Models of Prostate Cancer
142
Hepatocyte Growth FactorScatter Factor and Prostate Cancer Metastasis
197
Matrix Degradation in Prostate Cancer
220
The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates
253
Hormone Therapy for Prostate Cancer
282
Strategies for the Implementation of Chemotherapy and Radiotherapy
309
ImmunoGene Therapy for Metastatic Prostate Cancer
336
Distilling the Past Envisioning the Future
355
Index
399

βCatenin its Binding Partners and Signalling Mechanisms Implications in Prostate Cancer
171

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