Methods for Genetic Risk Assessment
Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well.
Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include:
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2-nitropropane alkylating agents analysis aneuploidy applied approach aquatic assay bioassay biological cancer carcinogenesis carcinogenic carcinogenic potency chemical mutagens chromosomal aberrations Claxton comparative compounds concentration contaminants cytogenetic detection developed disease DNA adducts DNA damage DNA repair dose-response dosimetry Ehling Ehrenberg emissions endpoints environment estimate ethyl ethylene oxide evaluation exposed exposure assessment exposure to genotoxic extrapolation factors frequency genetic damage genetic risk genotoxic agents genotoxic substance genotoxicants genotoxicity tests germ cells germ-cell human exposure IARC identify indoor induced ionizing radiation laboratory Lewtas Lohman mammalian cells measured metabolic methods methyl methanesulfonate mice micronuclei molecular monitoring mouse mutagenesis mutagenic mutagenic activity mutagenic effect mutation induction mutation rate Neuhäuser-Klaus organisms pathways pharmacokinetics plants pollutants population potential quantitative rats relationship relative repair response risk assessment risk characterization rodents Salmonella samples sensitivity short-term soil species specific-locus spermatogonia studies tissue toxicity Toxicol Toxicology U.S. EPA uptake vitro vivo
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