Methods for Skin Absorption
This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Penetrant Characteristics Influencing Skin Absorption
Preparation of Biological Membranes
agent analysis anesthesia animal model animal skins artificial membranes assay assessing Behl bioavailability biological blood Bronaugh chamber Chromatography compared cutaneous cyanoacrylate dermal dermal absorption dermal application Dermatol dermis detector determined diffusion cell donor compartment drug effects epidermis ethanol evaluation evaporation cell excretion experimental exposure extraction Figure finite dose flow rate flow-through Franz cell glass hairless mouse intravenous investigator IPPSF kinetics laboratory layer lipophilic liquid Maibach material measurements membrane Metabolism cages metabolites method mice molecules nude mouse partition coefficient penetration cell percutaneous absorption percutaneous penetration perfused permeation Pharm Pharmaceutical pharmacokinetic Pharmacol phase plasma concentration procedures rabbits radioactivity receptor fluid Reifenrath rodents sample scintillation skin absorption skin flap skin grafts skin permeability skin preparations skin surface solubility solution solvent species steroids stratum corneum substance technique Teflon temperature test compound thickness tissue topically applied toxicity Toxicol transdermal transport urine vehicle vitro vivo volatile volume
Pharmaceutical Preformulation and Formulation: A Practical Guide from ...
No preview available - 2001