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Specific Questions Relating to Drug Treatment of Advanced Clinically
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activity adriamycin alkylating agents animals anticancer drugs antimetabolite antineoplastic antitumor Ara-C bleomycin bone marrow breast cancer C0MPLETE Cancer Chemother Cancer Chemotherapy Cancer Philadelphia Cancer Res cellular clearance combination chemotherapy compared compounds cure cyclophosphamide disease dose drug treatment effects enzyme evaluation example excretion experimental exponential factors fluorouracil Frei Freireich Gompertzian growth fraction Guarino increase individual tumor initial levels liver lung lymphoma M. D. Anderson Hospital major MEDIAN LIFE SPAN metabolism metabolites methotrexate MG/KG mice Mitomycin monkey murine neoplastic number of patients observed occur osteogenic sarcoma pharmacokinetic Pharmacol pharmacologic Phase I trial phenomenological physician plasma PR rates predictive prednisone Procarbazine randomized clinical trial RANGE 0F DEATHS ratios renal response rate Schabel schedule Schein shark solid tumors species Table testing therapeutic therapy tion tissues toxicity toxicologic tumor tumor cells tumor growth tumor regression urine variable vincristine volume