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Cancer Drugs of Microbial Origin
Drugs of Plant Origin
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acid actinomycin adenosine adriamycin Alkaline elution alkylating agents animal tumors anthracycline antibiotics anticancer agents antimetabolites antitumor activity antitumor agents Ara-C ascites assay binding Biochem Biol Biophys bleomycin Cancer Chemother Cancer Res carcinoma carrier cell lines Chem chemical chemotherapy clinical activity clinical trials complex compounds concentration cross-links cyclophosphamide cytotoxicity daunomycin derivatives dihydrofolate reductase dose drug effect efflux enzyme experimental extracts folate folate analogs fraction Goldin Hakala human tumor hypoxanthine influx inhibition inhibitors intracellular isolated kinetics Kohn leukemia leukemia L1210 mammalian cells maytansine mechanism membrane metabolism methotrexate mice molecules mouse nitrogen mustard nucleoside Plagemann plant polymer predicted produced protein purine pyrimidine sarcoma screening selection sensitive single-strand breaks Sirotnak solid tumors specific strand structural studies substrate synthesis synthetic Table therapeutic thymidine tion toxicity transport systems treatment tumor tumor cells tumor systems uptake uridine vincristine vitro vivo xenografts