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Cancer Drugs of Microbial Origin
chapter in Drugs of Plant Origin
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acid adenosine adriamycin alkaline elution alkylating agents animal tumors antibiotics anticancer agents antimetabolites antitumor activity antitumor agents Ara-C ascites assay binding Biochem Biol Biophys bleomycin Cancer Chemother Cancer Res carcinoma carrier cell lines Chem chemical chemotherapy clinical activity clinical trials complex compounds concentration cross-links cyclophosphamide cytotoxicity daunomycin derivatives dihydrofolate reductase dose drug effect efflux enzyme experimental extracts folate folate analogs fraction Goldin Hakala human tumor hypoxanthine influx inhibition inhibitors intracellular isolated kinetics Kohn leukemia leukemia L1210 mammalian cells maytansine mechanism membrane metabolism methotrexate mice mitomycin molecular molecules mouse nitrogen mustard nucleoside Plagemann plant polymer predicted produced protein purine pyrimidine sarcoma screening sedimentation selection sensitive single-strand breaks Sirotnak solid tumors specific strand structural studies substrate synthesis synthetic Table therapeutic thymidine tion toxicity transport systems treatment tumor tumor cells tumor systems uptake uridine vincristine vitro vivo xenografts