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Specific Questions Relating to Drug Treatment of Advanced Clinically
New Thoughts on the Relationship of Tumor
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activity adriamycin alkylating agents animals anticancer drugs antimetabolite antineoplastic antitumor Ara-C biochemical bleomycin bone marrow breast cancer Cancer Chemother Cancer Chemotherapy Cancer Philadelphia Cancer Res Cancer Treat cellular clearance Clin combination chemotherapy compared compounds cure cyclophosphamide DAYS POSTIMPLANT disease dose drug treatment effects enzyme evaluation example excretion experimental exponential fluorouracil Frei Freireich Gompertzian Guarino human tumors increase individual tumor initial levels liver lung lymphoma M. D. Anderson Hospital major MEDIAN LIFE SPAN metabolism metabolites methotrexate MG/KG mice monkey neoplastic nitrogen mustard nitrosoureas number of patients observed occur pharmacokinetic Pharmacol pharmacologic Phase I trial physician plasma PR rates predictive prednisone Proc Procarbazine randomized clinical trial RANGE OF DEATHS ratios renal response rate Schabel schedule Schein shark solid tumors species Table testing therapeutic therapy tion tissues toxicity toxicologic tumor tumor cells tumor growth urine variable vincristine volume