Methods to Assess DNA Damage and Repair: Interspecies Comparisons
Robert G. Tardiff, Paul H. M. Lohman, Gerald N. Wogan, Scientific Group on Methodologies for the Safety Evaluation of Chemicals
Wiley, Aug 16, 1994 - Science - 257 pages
Integrates data obtained from a variety of disciplines to evaluate the current state of knowledge regarding defense mechanisms and applies this information to estimate health risks to humans exposed to substances that alter genetic material. Recognized experts document, to a large extent, which carcinogens can cause injury to human beings and their surroundings, providing guidance for the structured acquisition of key information to reduce cancer risks throughout the environment.
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Introduction General Conclusions and Recommendations
DNA Repair and Mutagenesis
DNA Repair Mutagenesis and Risk Assessment
10 other sections not shown
acid active genes aflatoxin Albertini alkylating agents analysis aneuploidy animals aromatic assay assessment benzo[a]pyrene binding bioassays Biol biological Cancer Res Carcinogenesis carcinogens cell line cerevisiae CHO cells chromatin chromosomal aberrations cloning complementation group compounds correlation cross-linking cyclobutane database deletions descriptors detected DNA adducts DNA damage DNA repair dose Drosophila effects endpoints Environmental enzymes epoxide Escherichia coli eukaryotic evaluation excision-repair exposure gene genetic genome genotoxic guanine hprt hprt mutations human cells Interspecies lesions levels liver locus lymphocytes mammalian cells mechanisms metabolism metabolites method methylating mice micronuclei molecular mouse mutagenesis mutagenic mutation frequency mutational specificity mutational spectra mutations induced Natarajan Natl Acad nucleophilic nucleotide observed photoproducts preferential repair Proc protein pyrimidine dimers RAD3 radiation RBCs reactive removal replication rodent shuttle vector spectrum spontaneous strand structure studies synthesis target TDso tissues transfection tumor vitro vivo Wogan xeroderma pigmentosum yeast