Methuselah Flies: A Case Study in the Evolution of Aging

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World Scientific, 2004 - Science - 479 pages
Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging. Methuselah Flies: is a tightly edited distillation of twenty years of work by many scientists; contains the original publications regarding the longer-lived fruit flies; offers commentaries on each of the topics covered - new, short essays that put the individual research papers in a wider context; gives full access to the original data; captures the scientific significance of postponed aging for a wide academic audience.
 

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Contents

The Creation of Methuselah Flies by Laboratory Evolution
3
Evolutionary Patterns among Measures of Aging
40
Increasing Stress Resistance Often Postpones Aging
53
Metabolic Reserves and Evolved Stress Resistance in Drosophila
56
Physiological Mechanisms of Evolved Desiccation Resistance
89
Postponed Aging and Desiccation Resistance in Drosophila melanogaster
101
Reproduction Nutrition and Aging
117
Metabolic Aspects of the Tradeoff between Fecundity and Longevity
145
Electrophoretic Analysis of Methuselah Flies from Multiple Species
237
Reverse Evolution of Aging
251
Desiccation Flight Glycogen and Postponed Senescence in Drosophila
264
Variation in the Reversibility of Evolution
283
Reverse Evolution of Aging in Drosophila melanogaster
296
Relaxed Stress Selection in Drosophila melanogaster
323
Aging Development and Crowding
355
Experimental Evolution of Accelerated Development in Drosophila
390

The Evolution of Development in Drosophila melanogaster Selected
187
Genetics and Molecular Biology of Methuselah Flies
193
Allozymic Differentiation in Response to Laboratory Demographic
196
Twodimensional Protein Electrophoretic Analysis of Postponed Aging
205
Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected
229
Correlations between
406
Experimental Evolution of Accelerated Development in Drosophila
413
Author Index
441
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About the author (2004)

Michael R. Rose is Professor of Evolutionary Biology at the University of California at Irvine and is Director of the University of California Intercampus Research Program on Experimental Evolution.

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