Microbial Genomics and Drug Discovery
Thomas J. Dougherty, Steven J. Projan
CRC Press, May 14, 2003 - Science - 264 pages
Examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. Explores potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of drug discovery processes. Illustrates the use of Pathway Tools in a genomics-based drug discovery project.
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Acad Sci USA activity agents analysis antibiotic resistance antifungal antigens antimicrobial approach assays aureus bacterial Bacteriol biochemical bioinformatics Biol biosynthesis cell cerevisiae chemical chromosome clinical clones coli combinatorial complete genome compounds Curr database detect disease DNA microarrays drug discovery drug targets electrophoresis encoded enzyme Escherichia coli essential genes function fungal gene expression gene knockouts gene products genetic genome sequence global growth Helicobacter pylori high-throughput homology host Immun infection inhibition inhibitors insertion interactions isolated ligands metabolic metabolites methods microbial genome Microbiol molecular molecules mRNA multiple mutants Natl Acad Sci natural products novel Nucleic Acids Res ORFs organisms pathogens peptide PGDB phage display phenotype Phenotype MicroArrays plasmid polyketides Proc Natl Acad protein proteomics recombinant response result screening secondary metabolites selection specific spots strains strategy structure studies surrogate target gene techniques therapy tion transcription transposon tuberculosis vaccine virulence vitro vivo