Microbial Functional Genomics
Wiley, Mar 19, 2004 - Medical - 590 pages
Genomics: toward a genome-level understanding of the structure, functions, and evolution of bioloical systems; Microbial diversity and genomics. Computational genome annotation. Microbial evolution from a genomics perspective. Computational methods for functional prediction of genes. DNA microarray technology. Microarray gene expression data analysis. Mutagenesis as a genomic tool for studying gene function. Mass spectrometry. Identification of protein-ligand interactions. The functional genomics of model organisms: addressing old questions from a new perspective. Functional genomic analysis of bacterial pathogens and environmentally significant microorganisms. The impact of genomics on antimicrobial drug discovery and toxicology. Application of microarray-based genomic technology to mutation analysis and microbial detection. Future perspectives: genomics beyond single cells.
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Toward a Genomelevel Understanding of the Structure
Microbial Diversity and Genomics
Computational Genome Annotation
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2D-PAGE algorithm alignment allele amino acid analysis analyzed antisense approach Archaea array bacterial binding biological cDNA cell cellular cerevisiae chromosome cloning coli complex data clustering data points data set database deletion detection diversity DNA microarrays domain duplication encoded enzyme essential genes eukaryotes evolution evolutionary example experimental expression levels expression profiles fluorescent fragments functional genomics fusion gene expression gene expression data gene function gene prediction genetic genome sequence high-throughput homologous hybridization identified insertion ions labeled lineages mass spectrometry measurement metabolic method methodology microarray microbial genomes molecular clock molecular mass molecules mRNA MS/MS multiple mutagenesis mutants networks oligonucleotide operon ORFs organisms orthologous pathways peptides phage phenotype phylogenetic plasmid probes prokaryotic protein–protein interactions proteome recombination regions regulatory replication rRNA sample selection signal slide species spots strains structure studies surface tags technique transcription transposon two-hybrid vector vivo whole-genome yeast