Microbial resistance to drugs

Front Cover
Springer, 1989 - Medical - 451 pages
This volume serves as a reference source for those studying, investigating and teaching the use and development of antimicrobial agents. One of the principal objectives is to discuss resistance to antimicrobial agents emphasizing understanding mechanisms of resistance both at the fundamental and molecular level. At the same time the book tries to provide an overview of the plasmid basis of resistance, modern methods to detect resistance, a molecular approach to the epidemiology of resistance and adaptive processes used by microbes to persist in the presence of antibiotics. In many cases the clinical significance of resistance mechanisms has also been examined. Each chapter is written by acknowledged experts in their field, together they represent the most in depth presentation of our current understanding of mechanisms of antimicrobial resistance available today.

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Contents

CHAPTER
1
Permeability of Bacterial Outer Membranes to Lactam Antibiotics
9
CHAPTER
11
Intrinsically Resistant Organisms
18
G Outer Membrane Permeability to Polycationic Agents
24
CHAPTER 2
35
B Antimicrobial Resistance Associated with Antimicrobial Transport
36
References
53
CHAPTER 9
193
Changes in Ribosomal RNA Which Result in Antimicrobial Resistance
205
Antibiotics and Phylogeny
211
CHAPTER 10
227
Concluding Remarks
244
Resistance to Trimethoprim
249
Epidemiology of Trimethoprim Resistance
271
Mechanism and Epidemiology of Trimethoprim Resistance in Gram
278

CHAPTER 3
59
Mechanism of Chloroquine Resistance
68
CHAPTER 4
77
Laboratory Studies on the Development of LactamResistant PBPs
81
References
97
Classification of BetaLactamases
103
F Spread of PlasmidDetermined BetaLactamases in Patient Flora
113
G Contribution of PlasmidDetermined BetaLactamases to BetaLactam
119
CHAPTER 6
129
Oxyiminocephalosporinases
138
G Subclassification Scheme for Chromosomal BetaLactamases
144
CHAPTER 7
151
E Conclusion
163
CHAPTER 8
169
Mechanisms of Resistance
175
E Summary and Conclusions
187
CHAPTER 12
291
Mode of Action of Sulfonamides
297
F Genetics of Sulfonamide Resistance
304
CHAPTER 13
313
CHAPTER 14
325
References
351
CHAPTER 15
359
DNA Probes for AST
374
CHAPTER 16
387
Epidemic Plasmids
394
References
405
CHAPTER 17
411
References
418
GramNegative Aerobic Bacilli
428
Subject Index
441
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