Microdialysis in Drug Development
Markus M Ller
Springer Science & Business Media, Sep 11, 2012 - Medical - 340 pages
In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
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acid activity adipose tissue administration Anal Chem analysis analyte animals application aqueous humor assessment BBB transport Benfeldt bioequivalence biomarkers blood flow blood-brain barrier blood–brain barrier brain ECF Brunner calibration capillary cefpirome cells Chromatogr Clin Pharmacol clinical cOFM cytokines Danhof Derendorf dermal microdialysis detection diabetes dialysate diffusion disease distribution dose drug concentrations drug development effect Epub ertapenem evaluation extracellular fluid flow rate glucose Hammarlund-Udenaes human implantation increase insertion insulin interstitial fluid investigated ischemia Jansson Kp,uu lactate Lange lipophilic Lönnroth Lunte measured membrane Metab metabolism metabolites method microdialysis probe microdialysis sampling microdialysis studies microdialysis technique microdosing molecular weight molecules monitoring morphine moxifloxacin Müller Neurosci ocular pain patients penetration peptide perfusion Pharm Res Pharmaceutical pharmacokinetics Physiol plasma positron emission tomography profiles prostaglandin proteomics quantitative receptors skin Stenken subcutaneous synaptic target tariquidar topical tumor unbound drug Ungerstedt vitreous vitro vivo microdialysis vivo recovery Wang