Minutes of the Phase I Working Group Meeting and Biochemical Modulators Advisory Group Meeting, July 9-10, 1984
Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, 1984 - Cancer - 401 pages
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PRESENTATION FROM BMAG MEETING JANUARY 1984
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acid Acivicin acodazole ADENOCARCINOMA administration agent Allopurinol antitumor activity assay bilirubin biochemical biosynthesis bolus Cancer Treat CARACEMIDE Carboplatin chemotherapy chest pain clinical trials compound concentration continuous infusion courses cystathionine cysteine decrease depletion diarrhea Dipyridamole dosage dose escalations dose level dose-limiting dose-limiting toxicity drug Echinomycin effects elevations enzymes evaluable Florida July 1984 FUra glutathione Headache hepatic hepatocytes hour infusion HPLC inhibition inhibitor July 1984 TABLE Kidney L/mz Lethargy liver lung lymphocyte M.D. Anderson MeCCNU Median metabolism mg/m mg/mz mild modulation MSKCC Myalgia Myelosuppression nadir nausea nausea and vomiting NCI July NCI-Canada PALA performance status pharmacokinetic pharmacokinetic parameters Phase I Study PHASE I TRIALS plasma platelet redox renal San Antonio sarcoma schedule serum creatinine SGPT SLIDE Stanford July 1984 strand breaks TCAR therapeutic therapy thiol thrombocytopenia Tiazofurin tissue topoisomerase toxicity treatment ug/ml urine Wisconsin