Mitochondria and Their Role in Cardiovascular Disease

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Springer Science & Business Media, Nov 19, 2012 - Medical - 500 pages
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Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.


 

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Contents

Section II Heart Mitochondria Signal Transduction Stem Cells
145
Section III Stress and Cell Death
202
Section IV Mitochondria in Pediatric Cardiology
242
Section V The Aging Heart and Mitochondria
271
Section VI Mitochondria in Atherosclerosis Hypertension and Ischemia
292
Section VII Mitochondria in Heart Failure and Dysrhythmias
326
Section VIII Mitochondria in Heart Metabolism
384
Section IX Mitochondrial Therapy
428
Section X Looking to the Future of Mitochondria and the Heart
453
Glossary
475
Index
485
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About the author (2012)

José Marín-García, MD

The Molecular Cardiology and Neuromuscular Institute

Highland Park, NJ, USA

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