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IDENTIFICATION AND EXPERIMENT DESIGN
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acetyl CoA adaptive control algorithm analysis anesthesia antigen application approach assumed assumptions behavior Biomed Biomedical Systems C-peptide calculated cell clinical closed-loop Cobelli compartment compartmental models concentration constant constraints coworkers cycle D-optimal described Design of experiments determined diabetic differential equations DiStefano distribution dose drug dynamics effect error evaluation experiment design experimental exponential flowAB function given gluconeogenesis Halothane hypotension identifiable IEEE Trans infusion rate initial input insulin isoflurane isotope kernels kinetics labeled labetalol Landaw least squares leucine levodopa linear lymphocytes mannitol mathematical model matrix measurements metabolism method minimal mmHg model parameters muscle noise nonlinear observed obtained output parameter estimation patients pharmacokinetic Physiol physiological plasma pool prediction problem procedure Pronzato protein pyruvate qualitative regulation response S-system sampling Savageau self-tuning control sensitivity set point shown simulation sodium nitroprusside solution theory tion tissue tracer values variables variance vector Wiener zero